Novel missense polymorphism in the regulator of G‐protein signaling 10 gene: analysis of association with schizophrenia

• Published in: Psychiatry and clinical neurosciences Vol. 58; no. 5; pp. 579 - 581
• Main Authors: HISHIMOTO, AKITOYO, SHIRAKAWA, OSAMU, NISHIGUCHI, NAOKI, AOYAMA, SHINSUKE, ONO, HISAE, HASHIMOTO, TAKESHI, MAEDA, KIYOSHI
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01-10-2004; Blackwell Publishing
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Alleles; Amino Acid Substitution - genetics; Biological and medical sciences; Case-Control Studies; Chromosomes, Human, Pair 10; Female; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Genetic Testing; Genotype; GTPase‐activating protein; G‐protein‐coupled receptor; Humans; Japan; Male; Medical sciences; Middle Aged; Mutation, Missense - genetics; Open Reading Frames - genetics; polymorphism; Polymorphism, Genetic - genetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; regulator of G‐protein signaling; RGS Proteins - genetics; RGS10; Risk Factors; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - genetics; Schizophrenic Psychology; Japan; Human; Pathophysiology; G-protein-coupled receptor; Regulator gene; Schizophrenia; Vulnerability; Case control study; Genetic determinism; Psychosis; Missense mutation; GTPase-activating protein; regulator of G-protein signaling; RGS10; Genetics; Polymorphism; G protein
• ISSN: 1323-1316; 1440-1819
• DOI: 10.1111/j.1440-1819.2004.01303.x

ABSTRACT  Dysfunction of neuronal signal transduction via G‐protein has previously been speculated to be involved in the pathophysiology of schizophrenia. Regulator of G‐protein signaling (RGS) is a protein that acts as a GTPase‐activator for Gα protein. A total of 33 Japanese patients with schizophrenia were screened for mutations in the coding region of the RGS10 gene, and a novel missense polymorphism (Val38Met) in the RGS domain was detected. A case‐control study did not reveal a significant association between this polymorphism and schizophrenia. The results do not provide evidence that the RGS10 gene is involved in biological vulnerability to schizophrenia.