Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population

METHODS: Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38 endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPV18 in the same samples using type-specific E6/E7 primers....

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Published in:	World journal of gastroenterology : WJG Vol. 11; no. 8; pp. 1200 - 1203
Main Authors:	Farhadi, Mohammad, Tahmasebi, Zahra, Merat, Shahin, Kamangar, Farin, Nasrollahzadeh, Dariush, Malekzadeh, Reza
Format:	Journal Article
Language:	English
Published:	United States Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran%Department of Molecular Biology, Khatam Postgraduate Faculty, Tehran, Iran%Cancer Prevention Studies Branch, US National Cancer Institute, Bethesda, MD, USA 28-02-2005 Baishideng Publishing Group Inc
Subjects:	Adult Aged Brief Reports Carcinoma, Squamous Cell - epidemiology DNA, Viral - analysis Esophageal Neoplasms - epidemiology Female Humans Iran - epidemiology Male Middle Aged Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - epidemiology Prevalence Risk Factors 乳头瘤病毒流行病学疾病调查食道鳞状细胞癌 Iran Papillomavirus Squamous cell carcinoma of esophagus Population
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Summary:	METHODS: Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38 endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPV18 in the same samples using type-specific E6/E7 primers. RESULTS: Fourteen (36.8%) of the 38 ESCC samples but only 5 (13.2%) of the 38 control samples were positive for the HPV L1 gene (P = 0.02). Five (13.2%) of the ESCC samples but none of the control samples were positive for the HPV16 E6/E7gene (P = 0.05). Three (7.9%) of the ESCC samples and 5 (13.2%) of the control samples were positive for the HPV18 E6/E7gene (P = 0.71). CONCLUSION: Our data are consistent with HPV DNA studies conducted in other high-risk areas for ESCC. HPV should be considered as a potential factor contributing to the high incidence of ESCC in Iran and other high-incidence areas of the world.
Bibliography:	14-1219/R R735.1 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correspondence to: Professor Reza Malekzadeh, Digestive Disease Research Center, Shariati Hospital, North Kargar Avenue, Tehran 14114, Iran. malek@ams.ac.ir Telephone: +98-21-8012992 Fax: +98-21-2253635 Author contributions: All authors contributed equally to the work.
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v11.i8.1200