A focus on parietal cells as a renewing cell population

The fact that the acidsecreting parietal cells undergo continuous renewal has been ignored by many gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using 3Hthymidine radioautography in combination with electron microscopy, it was possible...

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Bibliographic Details
Published in:	World journal of gastroenterology : WJG Vol. 16; no. 5; pp. 538 - 546
Main Author:	Karam, Sherif M
Format:	Journal Article
Language:	English
Published:	United States Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain PO Box 17666, United Arab Emirates 07-02-2010 Baishideng
Subjects:	Animals Cell Differentiation - physiology Cell Lineage Cell Movement - physiology Cell Proliferation Epithelial Cells - cytology Epithelial Cells - physiology Gastric Mucosa - cytology Gastric Mucosa - metabolism Humans Mice Parietal Cells, Gastric - cytology Parietal Cells, Gastric - physiology Stem Cells - cytology Stem Cells - physiology Oxyntic gland Parietal cell Preparietal cell Cell differentiation Cell renewal Cell dynamics Oxyntic mucosa
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Summary:	The fact that the acidsecreting parietal cells undergo continuous renewal has been ignored by many gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using 3Hthymidine radioautography in combination with electron microscopy, it was possible to demonstrate that parietal cells belong to a continuously renewing epithelial cell lineage. In the gastric glands, stem cells anchored in the isthmus region are responsible for the production of parietal cells...
Bibliography:	14-1219/R Cell differentiation; Cell dynamics; Cell renewal; Oxyntic gland; Oxyntic mucosa; Parietal cell; Preparietal cell Oxyntic gland R573 Parietal cell Preparietal cell Cell differentiation Cell renewal Cell dynamics Oxyntic mucosa SourceType-Other Sources-1 content type line 63 ObjectType-Editorial-2 ObjectType-Commentary-1 ObjectType-Article-3 Author contributions: Karam SM solely contributed to this paper. Correspondence to: Sherif M Karam, MD, PhD, Professor, Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain PO Box 17666, United Arab Emirates. skaram@uaeu.ac.ae Telephone: +971-3-7137493 Fax: +971-3-7672033
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v16.i5.538