Comparing AGS Beers 2019, STOPP version 2, and EU(7)-PIM list in Portuguese older adults in primary health care

• Published in: European journal of clinical pharmacology Vol. 80; no. 4; pp. 603 - 612
• Main Authors: Rodrigues, Daniela A., Herdeiro, Maria Teresa, Mateos-Campos, Ramona, Figueiras, Adolfo, Roque, Fátima
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-04-2024
• Subjects: Aged; Biomedical and Life Sciences; Biomedicine; Child; Female; Humans; Inappropriate Prescribing; Male; Pharmacology/Toxicology; Portugal; Potentially Inappropriate Medication List; Primary Health Care; Retrospective Studies; Portugal; EU-PIM list; AGS 2019 Beers criteria; STOPP v2 criteria; Primary health care; Older adults; Potentially inappropriate medications
• ISSN: 0031-6970; 1432-1041
• DOI: 10.1007/s00228-024-03633-5

Purpose
This study aims to identify PIM prevalence in older adults according to the 2019 Beers criteria, Screening Tool of Older Person’s Prescriptions version 2 (STOPP v2) criteria, and the Portuguese EU(7)-PIM list and also to analyze the concordance between these criteria.
Methods
A retrospective study was conducted among 1200 Portuguese older adults (≥ 65 years old), users of primary health care. Demographic, clinical, and pharmacological data were collected concerning the period between April 2021 and August 2022. A comparative analysis was performed between the three PIM identification criteria, and the concordance was determined according to the Lin concordance correlation coefficient.
Results
The mean age was 76.3 (SD 7.7) years old and 57.6% of the older adults were females. Our findings indicate varying prevalence rates among these criteria with 63.8% (95% CI 61.0–66.6%), 66.8% (95% CI 64.1–69.5%), and 50.1% (95% CI 47.2–53.0%) of the older adults take at least one PIM according to the EU(7)-PIM list, Beers 2019, and STOPP v2 criteria, respectively. The highest prevalence observed was for proton pump inhibitors according to EU(7)-PIM list (30.1%, 95% CI 27.6–32.9) and Beers criteria (30.1%, 95% CI 27.6–32.9) and alprazolam according to STOPP v2 criteria (10.1%, 95% CI 8.4–11.9%). A poor concordance between criteria was observed (< 0.834). The highest concordance coefficient was found between the EU(7)-PIM list and the Beers criteria (0.833), and the lowest between the EU(7)-PIM list and STOPP criteria (0.735).
Conclusion
This study reveals varying prevalence rates of PIM in older adults, as assessed by different criteria, and highlights the need for targeted interventions and improved prescribing practices. In the future, studies should focus on the occurrence of negative outcomes in older adults associated with PIM consumption.