Insights into the Management of Chronic Hepatitis in Children-From Oxidative Stress to Antioxidant Therapy

• Published in: International journal of molecular sciences Vol. 25; no. 7; p. 3908
• Main Authors: Ioniuc, Ileana, Lupu, Ancuta, Tarnita, Irina, Mastaleru, Alexandra, Trandafir, Laura Mihaela, Lupu, Vasile Valeriu, Starcea, Iuliana Magdalena, Alecsa, Mirabela, Morariu, Ionela Daniela, Salaru, Delia Lidia, Azoicai, Alice
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-04-2024
• Subjects: Antioxidants; Antioxidants - therapeutic use; Biomarkers; Child; children; Chronic diseases; chronic hepatitis; Development and progression; FDA approval; Health aspects; Hepatitis; Hepatitis A; Hepatitis B; Hepatitis C; Hepatitis, Chronic; Humans; Inflammation; Oxidative Stress; chronic hepatitis; antioxidants; children; oxidative stress
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25073908

Recent research has generated awareness of the existence of various pathophysiological pathways that contribute to the development of chronic diseases; thus, pro-oxidative factors have been accepted as significant contributors to the emergence of a wide range of diseases, from inflammatory to malignant. Redox homeostasis is especially crucial in liver pathology, as disturbances at this level have been linked to a variety of chronic diseases. Hepatitis is an umbrella term used to describe liver inflammation, which is the foundation of this disease regardless of its cause. Chronic hepatitis produces both oxidative stress generated by hepatocyte inflammation and viral inoculation. The majority of hepatitis in children is caused by a virus, and current studies reveal that 60-80% of cases become chronic, with many young patients still at risk of advancing liver damage. This review intends to emphasize the relevance of understanding these pathological redox pathways, as well as the need to update therapeutic strategies in chronic liver pathology, considering the beneficial effects of antioxidants.