A narrative literature review of remaining male reproductive health concerns as an aspect of persistent/late-onset complications of COVID-19

A narrative literature review of remaining male reproductive health concerns as an aspect of persistent/late-onset complications of COVID-19

Background Although COVID-19 infection has dropped across the world and SARS-CoV-2 vaccines have been developed, global concerns remain about the disease's long-term health consequences. The purpose of this research was to review the consequences of SARS-CoV-2 on male health, particularly the r...

Full description

Saved in:
Bibliographic Details
Published in:Middle East Fertility Society Journal Vol. 28; no. 1; pp. 30 - 9
Main Authors: Allahveisi, Azra, Afradiasbagharani, Parivash, Bazrafkan, Mahshid, Kafaeinezhad, Raheleh, Hosseini, Elham
Format: Journal Article
Language:English
Published: Cairo Springer 01-12-2023
Springer Nature B.V
SpringerOpen
Subjects:
Apoptosis
COVID-19
Cytokine storm
Infections
Infertility
Inflammation
Ischemia
Kinases
Leukocytes
Male health
Motility
Oxidative stress
Patients
Prostate
Reproductive health
Reproductive organs
Reproductive system
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Sperm
Spermatogenesis
Testes
Testosterone
Viral infections
Viruses
Iran
Mexico
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Although COVID-19 infection has dropped across the world and SARS-CoV-2 vaccines have been developed, global concerns remain about the disease's long-term health consequences. The purpose of this research was to review the consequences of SARS-CoV-2 on male health, particularly the reproductive system and the pathogenic mechanisms affecting male infertility. Improving knowledge on these issues may help in considering to which extent some of the remaining concerns should be addressed. Results The primary target of this disease is the pulmonary system, but reproductive organs may be targeted by the virus. To enter host cells, the virus utilizes both ACE2 and TMPRSS2, which are differentially expressed in the spermatogonial stem, Leydig, and Sertoli cells, thereby providing possible testicular vulnerability. COVID-19-related stress and psychological distress may also affect aspects of male reproductive health. Conclusions Since some pathological effects of COVID-19 infection and dysregulations are linked to infertility, more attention is needed to determine whether such dysregulations regress following infection decline.
ISSN:1110-5690
2090-3251
DOI:10.1186/s43043-023-00156-4