Is restless legs syndrome associated with chronic mountain sickness?

• Published in: Sleep medicine Vol. 16; no. 8; pp. 976 - 980
• Main Authors: Vizcarra-Escobar, Darwin, Mendiola-Yamasato, Andrea, Risco-Rocca, Jorge, Mariños-Velarde, Alejandro, Juárez-Belaunde, Alan, Anculle-Arauco, Victor, Rivera-Chira, María
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-08-2015
• Subjects: Adolescent; Adult; Aged; Altitude Sickness - blood; Altitude Sickness - complications; Altitude Sickness - epidemiology; Chronic Disease; Chronic mountain sickness; Cross-Sectional Studies; Electrocardiography; Hematocrit; Humans; Hypoxia; Logistic Models; Male; Middle Aged; Neurology; Oxygen - blood; Peru; Peru - epidemiology; Restless legs syndrome; Restless Legs Syndrome - blood; Restless Legs Syndrome - etiology; Severity of Illness Index; Sleep Medicine; Spirometry; Surveys and Questionnaires; Young Adult; Peru; Pittsburgh Sleep Quality Index; Chronic mountain sickness; Restless legs syndrome; hHAD; International Restless Leg Syndrome Study Group; Hypoxia; IRLSSG; Peru; PSQI; healthy high-altitude dwellers
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2015.03.013

Highlights • Limbo subjects had the highest restless legs syndrome (RLS) severity score. • Chronic mountain sickness (CMS) subjects had the lowest oxygen saturation and the highest hematocrit values. • O2 saturation, sleep quality, and Quinghai score of >5 were associated with RLS. • RLS could be an early clinical manifestation of hypoxia at high altitudes. • High-altitude dwellers could be a good model to study the role of hypoxia in RLS.