Current status of chemokine receptor inhibitors in development

Highlights ► Innovative drugs targeting CXC and CC receptors. ► Preclinical and clinical development of drugs acting on chemokine system. ► Perspectives on the development of novel Small Molecular Weight chemokine inhibitors.

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Bibliographic Details
Published in:	Immunology letters Vol. 145; no. 1; pp. 68 - 78
Main Authors:	Allegretti, Marcello, Cesta, Maria Candida, Garin, Alexandre, Proudfoot, Amanda E.I
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 30-07-2012
Subjects:	Allergy and Immunology Allosteric inhibitors Animals Autoimmune diseases CC receptor antagonists Cell Movement - drug effects Chemokine Chemokine receptors Chemokines - immunology Clinical trials Clinical Trials as Topic CXC Drug Discovery HIV Humans Inflammation Inflammatory diseases Metastases Molecular Targeted Therapy Pharmaceuticals Receptors, Chemokine - antagonists & inhibitors Small Molecule Libraries Tumors Chemokine Allosteric inhibitors HIV CC receptor antagonists Inflammatory diseases CXC
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Description
Summary:	Highlights ► Innovative drugs targeting CXC and CC receptors. ► Preclinical and clinical development of drugs acting on chemokine system. ► Perspectives on the development of novel Small Molecular Weight chemokine inhibitors.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Feature-1
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2012.04.003