Synthesis and cytotoxic and analgesic activities of some 1, 5-diaryl-3-ethoxycarbonylpyrrole derivatives

• Published in: Journal of enzyme inhibition and medicinal chemistry Vol. 21; no. 1; p. 113
• Main Authors: Demirayak, Seref, Beis, Rana, Karaburun, Ahmet C, Kayagil, Ismail, Incesu, Zerrin, Ucucu, Umit
• Format: Journal Article
• Language: English
• Published: England 01-02-2006
• Subjects: Analgesics - chemical synthesis; Analgesics - chemistry; Analgesics - pharmacology; Animals; Cell Proliferation - drug effects; Cells, Cultured; Embryo, Mammalian - cytology; Embryo, Mammalian - drug effects; Female; Fibroblasts - cytology; Fibroblasts - drug effects; Male; Mice; Pyrroles - chemical synthesis; Pyrroles - chemistry; Pyrroles - pharmacology; Rats; Tail - drug effects
• ISSN: 1475-6366
• DOI: 10.1080/14756360500472845

Some 1,5-diaryl-3-ethoxycarbonyl-2-methylpyrrole derivatives were obtained by reacting 1-aryl-3-ethoxycarbonylpent-1,4-diones and a suitable aniline derivative or sulfanilamide under Paal-Knorr pyrrole synthesis conditions. The cytotoxicity of the compounds was tested and all compounds, except for compound 2 h, showed a time-dependent increase in cytotoxic activity. Analgesic activities of the compounds were determined by using the tail-flick and tail-immersion methods; some of the compounds showed potent analgesic activity.