Delayed enhancement cardiovascular magnetic resonance as a novel technique to predict cardiac events in dilated cardiomyopathy patients

• Published in: International journal of cardiology Vol. 142; no. 3; pp. 224 - 229
• Main Authors: Shimizu, Ippei, Iguchi, Nobuo, Watanabe, Hiroyuki, Umemura, Jun, Tobaru, Tetsuya, Asano, Ryuta, Misu, Kazuhiko, Nagayama, Masatoshi, Aikawa, Masaru, Funabashi, Nobusada, Komuro, Issei, Sumiyoshi, Tetsuya
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 23-07-2010; Elsevier
• Subjects: Acute Disease; Aged; Biological and medical sciences; Cardiology. Vascular system; Cardiomyopathy, Dilated - diagnosis; Cardiomyopathy, Dilated - epidemiology; Cardiovascular; Cardiovascular magnetic resonance; Coronary Angiography; Delayed enhancement; Dilated cardiomyopathy; Echocardiography; Female; Heart; Heart Failure - epidemiology; Humans; Incidence; Kaplan-Meier Estimate; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Myocarditis. Cardiomyopathies; Predict cardiac events; Predictive Value of Tests; Ventricular Remodeling; Delayed enhancement; Cardiovascular magnetic resonance; Dilated cardiomyopathy; Predict cardiac events; Heart; Magnetic resonance; Cardiovascular disease; Myocardial disease; Nuclear magnetic resonance imaging; Delay; Congestive hypertrophic cardiomyopathy; Heart disease; Medical imagery; Technique; Cardiology; Predictive factor
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2008.12.189

Abstract Purpose Delayed enhancement cardiovascular magnetic resonance (DE-CMR) can detect cardiac scarring and has the potential to visualize the progression of myocardial remodeling. We determined whether DE-CMR can predict cardiac events in dilated cardiomyopathy patients. Materials and methods Transthoracic echocardiography, coronary arteriography, and DE-CMR studies were performed in 60 consecutive dilated cardiomyopathy (DCM) patients. Percent delayed enhancement (%DE) was determined as the ratio of the area showing delayed enhancement to the total myocardial area in three short-axis views. Patients were classified as advanced group (Group A) when %DE was 10% or higher, and as non-advanced group (Group NA) when %DE was less than 10%. The incidence of cardiac events and the clinical history were compared between Group A and Group NA. Results There were 11 patients in Group A and 49 patients in Group NA. The incidence of cardiac events was significantly higher in Group A (36%; 4/11 patients) than in Group NA (2.0%; 1/49 patients) (log rank, p = 0.0001). Conclusion DE-CMR is a useful tool to predict cardiac events in DCM patients.