Physiopathological role of extracellular vesicles in alloimmunity and kidney transplantation and their use as biomarkers

Antibody-mediated rejection is the leading cause of kidney graft dysfunction. The process of diagnosing it requires the performance of an invasive biopsy and subsequent histological examination. Early and sensitive biomarkers of graft damage and alloimmunity are needed to identify graft injury and e...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 14; p. 1154650
Main Authors:	Cuadrado-Payán, Elena, Ramírez-Bajo, María José, Bañón-Maneus, Elisenda, Rovira, Jordi, Diekmann, Fritz, Revuelta, Ignacio, Cucchiari, David
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 17-08-2023
Subjects:	biomarker exosomes extracellular vesicles Immunology kidney kidney transplant transplant
Online Access:	Get full text
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Summary:	Antibody-mediated rejection is the leading cause of kidney graft dysfunction. The process of diagnosing it requires the performance of an invasive biopsy and subsequent histological examination. Early and sensitive biomarkers of graft damage and alloimmunity are needed to identify graft injury and eventually limit the need for a kidney biopsy. Moreover, other scenarios such as delayed graft function or interstitial fibrosis and tubular atrophy face the same problem. In recent years, interest has grown around extracellular vesicles, specifically exosomes actively secreted by immune cells, which are intercellular communicators and have shown biological significance. This review presents their potential as biomarkers in kidney transplantation and alloimmunity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 These authors have contributed equally to this work Edited by: Long Zheng, The Second Affiliated Hospital of Zhejiang University School of Medicine, China Reviewed by: Vincenzo Cantaluppi, University of Eastern Piedmont, Italy; Sandhya Bansal, St. Joseph’s Hospital and Medical Center, United States
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2023.1154650