Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy

• Published in: Oral oncology Vol. 88; pp. 29 - 38
• Main Authors: Evrard, Diane, Szturz, Petr, Tijeras-Raballand, Annemilaï, Astorgues-Xerri, Lucile, Abitbol, Chloé, Paradis, Valérie, Raymond, Eric, Albert, Sébastien, Barry, Béatrix, Faivre, Sandrine
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-01-2019
• Subjects: Antineoplastic Agents - pharmacology; Cancer treatment; CSF-1R inhibitor; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - immunology; Head and Neck Neoplasms - virology; Humans; Immunomodulation; Macrophage Activation - drug effects; Macrophage Colony-Stimulating Factor - antagonists & inhibitors; Macrophages - classification; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Molecular Targeted Therapy - methods; Prognosis; Protumoral activities; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors; Targeted therapy; Tumor microenvironment; Tumor Microenvironment - immunology; Tumor-associated macrophages (TAMs); OSCC; CD163; TNM; Tumor microenvironment; TAMs; Targeted therapy; Cancer treatment; Tumor-associated macrophages (TAMs); Protumoral activities; CD68; CSF-1R inhibitor; HPV
• ISSN: 1368-8375; 1879-0593
• DOI: 10.1016/j.oraloncology.2018.10.040

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•Macrophages are frequently reported in the microenvironment of head and neck cancers.•Macrophages may harbor two phenotypes: antitumoral M1 or protumoral M2.•Macrophages in head and neck cancers have been associated with a poor prognosis.•Different strategies are developed toward macrophages as a therapeutic target.•Macrophages modulators are investigated alone or in combination with standard Therapies.
The microenvironment of solid tumors has become a promising target for future therapies modulating immune cells. Patients with advanced head and neck cancer, which still portends a poor outcome, are particularly in need of innovative approaches. In oral squamous cell carcinoma, high density of tumor-associated macrophages (TAMs) appears consistently associated with poor prognosis, whereas data are currently limited for other head and neck sites. Several approaches to block TAMs have been investigated, including TAMs inactivation by means of the colony stimulating factor 1 (CSF-1)/CSF-1 receptor (CSF-1R) inhibitors or strategies to reprogram TAMs from M2 protumoral phenotype toward M1 antitumoral phenotype. This review focuses on both prognostic and therapeutic aspects related to TAMs in head and neck carcinomas.