Perioperative factors associated with postoperative morbidity after emergency laparotomy: a retrospective analysis in a university teaching hospital

• Published in: Scientific reports Vol. 10; no. 1; p. 16999
• Main Authors: Ahmed, M., Garry, E., Moynihan, A., Rehman, W., Griffin, J., Buggy, D. J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12-10-2020
• Subjects: 692/499; 692/53/2422; 692/53/2423; 692/699/1503; Aged; Aged, 80 and over; Emergency Medical Services - statistics & numerical data; Female; Hemodynamics; Humanities and Social Sciences; Humans; Laparotomy - mortality; Male; Middle Aged; multidisciplinary; Perioperative Period; Postoperative Complications - epidemiology; Postoperative Complications - mortality; Retrospective Studies; Risk Assessment; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-73982-5

Emergency Laparotomy (EL) is associated with significant morbidity and mortality. Variation in practice and patient outcomes for patients undergoing emergency laparotomy has been identified through the UK National Emergency Laparotomy Audit (NELA), with 30-day mortality ranging from 11 to 15%. A correlation between preoperative haemodynamic parameters and increased postoperative mortality has been demonstrated by both NELA and other observational studies. The association between intraoperative haemodynamic parameters and overall postoperative morbidity has not been evaluated in EL patients. The aims of our study were to investigate the association between perioperative haemodynamic and logistic parameters and postoperative morbidity in a tertiary referral university hospital; and to compare our outcomes to that of the NELA data. A retrospective analysis correlating a range of perioperative parameters with Comprehensive Complication Index (CCI) among 86 patients who underwent EL during 2018 was conducted. Mean age was 64 years (SD 16). Median CCI was 27 [9–45], and 30-day mortality was 11.7%. Several intraoperative parameters correlated with CCI on univariate analysis. On multivariate analysis, ASA status (
P
 = 0.005) and unplanned escalation to postoperative intensive care (
P
 = 0.03) were independently associated with CCI. Our study shows a correlation between ASA status and unplanned escalation to ITU with increased postoperative morbidity in patients undergoing emergency laparotomy. We did not demonstrate an independent correlation between intraoperative parameters and postoperative morbidity. These findings warrant confirmation in a larger scale observational study. Outcomes in our institution are comparable to those seen in the NELA.