Application of platelet-rich plasma in rectovaginal fistulas in the patients with ulcerative colitis

• Published in: Langenbeck's archives of surgery Vol. 407; no. 1; pp. 429 - 433
• Main Authors: Hermann, Jacek, Cwaliński, Jarosław, Banasiewicz, Tomasz
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2022
• Subjects: Abdominal Surgery; Cardiac Surgery; Colitis, Ulcerative - therapy; Female; General Surgery; How-I-Do-It articles; Humans; Medicine; Medicine & Public Health; Platelet-Rich Plasma; Rectal Fistula; Rectovaginal Fistula - surgery; Thoracic Surgery; Traumatic Surgery; Treatment Outcome; Vascular Surgery; Inflammatory bowel diseases; Platelet-rich plasma; Rectovaginal fistulas
• ISSN: 1435-2443; 1435-2451
• DOI: 10.1007/s00423-021-02232-7

Background
There is a need for other than surgical methods of therapy for small and low rectovaginal fistulas (RVF) in the course of inflammatory bowel diseases (IBD), such as application of fibrin sealants, stem cells, biological therapy, or platelet-rich plasma. The aim of this study was to evaluate the results of the treatment after local application of PRP in aforementioned fistulas, exclusively in the patients with ulcerative colitis (UC).
Patients and methods
Medical records of 13 patients with small and low-lying, active RVF in the course of UC, and after restorative proctocolectomy for UC were evaluated. Curettage of fistulous tracts was performed with the following application of PRP in all patients.
Results
Complete closure of RVF was achieved after the first injection in 4 patients, 3 women healed their fistulas following the second application, and two of them closed RVF after 3 injections. To sum up, the complete closure of RVF was achieved in 9 (69%) patients. Fistulas remained closed from 6 to 12 months.
Conclusions
The application of PRP in small, low, and recurrent IBD anal fistulas is effective, simple, and safe with an acceptable rate of healing. This therapy might also precede any further, surgical methods of treatment.