Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease

• Published in: The New England journal of medicine Vol. 385; no. 17; pp. 1559 - 1569
• Main Authors: Sanyal, Arun J, Van Natta, Mark L, Clark, Jeanne, Neuschwander-Tetri, Brent A, Diehl, AnnaMae, Dasarathy, Srinivasan, Loomba, Rohit, Chalasani, Naga, Kowdley, Kris, Hameed, Bilal, Wilson, Laura A, Yates, Katherine P, Belt, Patricia, Lazo, Mariana, Kleiner, David E, Behling, Cynthia, Tonascia, James
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 21-10-2021
• Subjects: Adult; Adults; Ascites; Biopsy; Carcinoma, Hepatocellular - etiology; Cirrhosis; Clinical outcomes; Confidence intervals; Diabetes; Diabetes mellitus (non-insulin dependent); Diet; Encephalopathy; Enrollments; Fatty liver; Female; Fibrosis; Gastroenterology; Gastroenterology General; Gastrointestinal Hemorrhage - etiology; Glomerular filtration rate; Hemorrhage; Humans; Hypertension; Incidence; Kidney diseases; Laboratories; Liver - pathology; Liver cancer; Liver cirrhosis; Liver Cirrhosis - complications; Liver Cirrhosis - mortality; Liver Disease; Liver diseases; Liver Neoplasms - etiology; Male; Middle Aged; Mortality; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - mortality; Nutrition; Prognosis; Prospective Studies; Severity of Illness Index; Software; Statistical analysis; Transplants & implants
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa2029349

In a study involving patients with nonalcoholic fatty liver disease, all-cause mortality over a median of 4 years was higher among patients with advanced fibrosis at baseline than among those with lower fibrosis stages. Advanced fibrosis was related to an increased incidence of liver decompensation events.