new resveratrol trimer derivative from Gnetum brunonianum

• Published in: Journal of asian natural products research Vol. 14; no. 9; pp. 918 - 922
• Main Authors: Yao, Chun-Suo, Lin, Mao, Yang, Qing-Yun
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis Group 01-09-2012; Taylor & Francis; Taylor & Francis Ltd
• Subjects: anti-inflammatory activity; Biological and medical sciences; carbon; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; General pharmacology; gnetubrunol A; Gnetum; Gnetum - chemistry; Gnetum brunonianum; lianas; Medical sciences; Molecular Structure; nuclear magnetic resonance spectroscopy; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; resveratrol; resveratrol trimer; spectral analysis; stable isotopes; Stilbenes - chemistry; Stilbenes - isolation & purification; Stilbenes - pharmacology; Trimer; Gnetales; resveratrol trimer; Biological activity; Stilbene derivatives; anti-inflammatory activity; gnetubrunol A; Phytoalexin; Gymnospermae; Liana; Plant origin; Resveratrol; Phenols; Isolation; Spermatophyta; Gnetum brunonianum; Tumor necrosis factor α; Structural analysis
• ISSN: 1477-2213; 1028-6020; 1477-2213
• DOI: 10.1080/10286020.2012.695350

A new resveratrol trimer derivative, named as gnetubrunol A (1), together with five known stilbene derivatives, shegansu B (2), resveratrol (3), isorhapontigenin (4), gnetifolin E (5), and isorhapontigenin-11-O-β-d-glucopyranoside (6) were isolated from the lianas of Gnetum brunonianum Griff. Their structures were elucidated on the basis of spectral analysis (UV, IR, MS, ¹H NMR, ¹³C NMR, and 2D NMR). The anti-inflammatory activities of 1, 5, and 6 have also been assayed.