A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection

• Published in: The New England journal of medicine Vol. 387; no. 7; pp. 620 - 630
• Main Authors: Gutierrez Sanchez, L. Helena, Shiau, Henry, Baker, Julia M., Saaybi, Stephanie, Buchfellner, Markus, Britt, William, Sanchez, Veronica, Potter, Jennifer L., Ingram, L. Amanda, Kelly, David, Lu, Xiaoyan, Ayers-Millsap, Stephanie, Willeford, Wesley G., Rassaei, Negar, Bhatnagar, Julu, Bullock, Hannah, Reagan-Steiner, Sarah, Martin, Ali, Rogers, Michael E., Banc-Husu, Anna M., Harpavat, Sanjiv, Leung, Daniel H., Moulton, Elizabeth A., Lamson, Daryl M., St. George, Kirsten, Hall, Aron J., Parashar, Umesh, MacNeil, Adam, Tate, Jacqueline E., Kirking, Hannah L.
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 18-08-2022
• Subjects: Acute Disease; Adenovirus Infections, Human - complications; Adenovirus Infections, Human - diagnosis; Adenovirus Infections, Human - virology; Adenoviruses; Adenoviruses, Human - genetics; Age; Biopsy; Child; Child, Preschool; Children; Cholestasis; Coronaviruses; Diagnostic tests; Disease control; Electron microscopy; Electronic health records; Epstein-Barr virus; Gastroenterology; Gastroenterology General; Hepatitis; Hepatitis - virology; Humans; Immunocompetence; Infant; Infections; Infectious Disease; Liver; Liver Disease; Liver diseases; Liver transplantation; Medical laboratories; Medical records; Patients; Pediatrics; Pediatrics General; Polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2; Viral Infections; Viremia; Virology; Alabama; United States > US
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa2206294

A majority of children admitted to a single hospital in late 2021–early 2022 with acute hepatitis of unknown cause tested positive for adenovirus. This report describes the children’s illnesses and outcomes.