Super Early Scan of PSMA PET/CT in Evaluating Primary and Metastatic Lesions of Prostate Cancer

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 14; p. 4661
• Main Authors: Mao, Juanli, Gao, Mingjun, Cui, Bin, Zhang, Yingying, Wang, Xiaojiao, Liang, Siyu, Zuo, Changjing, Chen, Peng, Dong, Aisheng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21-07-2022; MDPI
• Subjects: 68Ga-PSMA-11 PET/CT; Animal models; Animals; Antigens; Bladder; Computed tomography; Correlation coefficient; Correlation coefficients; Diagnosis; Differential diagnosis; Diuretics; Edetic Acid; Evaluation; Gallium Isotopes; Gallium Radioisotopes; Humans; Lesions; Lymphatic system; Male; Medical imaging; Metabolism; Metastases; Metastasis; Mice; Nuclear medicine; Oligopeptides; Patients; Physiology; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography - methods; primary lesions; Prostate cancer; Prostatic Neoplasms - pathology; Scanning; Shielding; super early; Tomography; Beijing China; China; prostate cancer; primary lesions; super early; metastasis; 68Ga-PSMA-11 PET/CT
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27144661

68Ga-prostate specific membrane antigen (PSMA)-11 PET/CT has been widely used in the diagnosis of prostate cancer (PCa); however, the urine lead shielding resulting from the urinary metabolism of tracers may obstruct the detection of surrounding metastasis. In this research, the additive value of super early scanning in diagnosing primary lesions and metastasis in the pelvic cavity was evaluated. Firstly, the differentiation efficiency of 68Ga-PSMA-11 PET scanned at 3 min post-injection (min P.I.) was measured in PSMA-positive (22rv1 cells) and PSMA-negative (PC3 cells) model mice. Secondly, 106 patients were scanned at 3 min P.I. for the pelvic cavity and then scanned as a standard protocol at 45 min P.I. In the results, the differential diagnosis of PSMA expression was completely reflected as early as 3 min P.I. for mice models. For patients, when correlated with the Gleason score, the quantitative results of the super early scan displayed a comparable correlation coefficient with the routine scan. The target to bladder ratios increased from 1.44 ± 2.40 at 45 min to 10.10 ± 19.10 at 3 min (p < 0.001) for the primary lesions, and it increased from 0.99 ± 1.88 to 9.27 ± 23.03 for metastasis. Meanwhile, the target to background ratios increased from 2.21 ± 2.44 at 3 min to 19.13 ± 23.93 at 45 min (p < 0.001) for the primary lesions, and it increased from 1.68 ± 2.71 to 12.04 ± 18.73 (p < 0.001) for metastasis. In conclusion, super early scanning of 68Ga-PSMA-11 PET/CT added referable information for metastasis detection in order to avoid disturbing tracer activity in the urinary system.