Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L

• Published in: Journal of ethnopharmacology Vol. 89; no. 2; pp. 265 - 270
• Main Authors: KÜPELI, Esra, ERDEMOGLU, Nurgün, YESILADA, Erdem, SENER, Bilge
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-12-2003; Elsevier
• Subjects: Analgesics - isolation & purification; Analgesics - pharmacology; Analgesics - toxicity; Animals; Anti-inflammatory; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - toxicity; Antinociceptive; Benzoquinones; Biological and medical sciences; Carrageenan; Colic - chemically induced; Colic - drug therapy; Edema - chemically induced; Edema - drug therapy; General pharmacology; Lignans; Lignans - isolation & purification; Lignans - pharmacology; Lignans - toxicity; Male; Medical sciences; Mice; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - chemistry; Plant Stems - chemistry; Taxaceae; Taxoids; Taxoids - isolation & purification; Taxoids - pharmacology; Taxoids - toxicity; Taxus - chemistry; Taxus spec; Toxicity Tests, Acute; Taxus spec; Antinociceptive; Taxoids; Anti-inflammatory; Taxaceae; Lignans; Medicinal plant; Pain; Gymnospermae; Taxus baccata; Lignan; Phytotherapy; Pharmacognosy; Heartwood; Rodentia; Antiinflammatory agent; Inflammation; Analgesia; Vertebrata; Mammalia; Analgesic; Treatment; Mouse; Animal; Plant origin; Coniferales; Spermatophyta
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2003.09.005

Four taxoids (taxusin, baccatin VI, baccatin III and 1β-hydroxybaccatin I) and five lignans (lariciresinol, taxiresinol, 3′-demethylisolariciresinol-9′-hydroxyisopropylether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of
Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated. All the compounds were shown to possess significant antinociceptive activity against
p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice.