Orchitis reveals an extragonadal primary mediastinal thymic seminoma: a coincidence or not?

• Published in: World journal of surgical oncology Vol. 15; no. 1; p. 85
• Main Authors: Tampakis, Athanasios, Tampaki, Ekaterini Christina, Damaskos, Christos, Feretis, Themistoklis, Thymara, Irene, Kontzoglou, Konstantinos, Tomos, Periklis, Kouraklis, Gregory
• Format: Journal Article
• Language: English
• Published: England BioMed Central 13-04-2017; BMC
• Subjects: Adult; Biopsy; Cancer; Case Report; Chest; Computed tomography; Cough; Diagnosis, Differential; Differential diagnosis; Dysphagia; Dyspnea; Family medical history; Fever; Germ cells; Hemoptysis; Histology; Humans; Lymphocytes; Lymphoma; Male; Male germ cell tumors; Mediastinal Neoplasms - diagnosis; Mediastinal Neoplasms - surgery; Mediastinum; Molecular biology; Orchitis; Orchitis - pathology; Orchitis - surgery; Pain; Pathogenesis; Prognosis; Respiration; Seminoma; Seminoma - diagnosis; Seminoma - surgery; Surgery; Testicular intraepithelial neoplasia; Thymic seminoma; Thymus; Thymus Neoplasms - diagnosis; Thymus Neoplasms - surgery; Tumors; Weight loss; Young Adult; Testicular intraepithelial neoplasia; Orchitis; Thymic seminoma; Male germ cell tumors
• ISSN: 1477-7819; 1477-7819
• DOI: 10.1186/s12957-017-1146-z

Mediastinal thymic seminomas are rare male germ cell tumors with extragonadal origin that appear predominately with a cystic appearance.
A 22-year-old male was referred to our department for further investigation of a mediastinal mass discovered incidentally during routine chest X-ray. The patient has denied any symptoms including dyspnea, chest pain, cough, fever, dysphagia, hemoptysis, weight loss, and weakness. His past medical history was remarkable for orchitis, for which he had undergone a bilateral testicular biopsy, without the latter however, indicating the presence of a germ cell tumor or a premalignant lesion. Contrast-enhanced chest computed tomography revealed a lobulated and well-marginated cystic lesion in the anterior mediastinum. Differential diagnosis included mostly a multilocular thymic cyst, a lymphoma, a seminoma, or a soft tissue tumor. Resection of the mass revealed a primary thymic seminoma.
A surgical approach for the management of these tumors might be reasonable considering that an extensive sampling is mandatory to gain an appropriate biopsy preoperatively in order to securely confirm or refute the presence of a mediastinal extragonadal tumor. Orchitis might be a sign of a general disorder of the germ cells which might transform in time.