The correlation between KRAS and TP53 gene mutations and early growth of pulmonary nodules

• Published in: Journal of cardiothoracic surgery Vol. 19; no. 1; pp. 376 - 7
• Main Authors: Zhao, Bin, Li, Bin, Guo, Haoxin, Zhao, Qingtao, Zhang, Xiaopeng, Zhao, Huanfen, Xue, Wenfei, Li, Wei, Duan, Guochen, Xu, Shun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26-06-2024; BioMed Central; BMC
• Subjects: Adult; Aged; Correlation; DNA Mutational Analysis; Early pulmonary nodules; Female; Gene loci; Gene mutations; Genes; Genes, p53 - genetics; Genetic testing; Growth; Humans; KRAS; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Lung nodules; Male; Middle Aged; Mortality; Multiple Pulmonary Nodules - diagnostic imaging; Multiple Pulmonary Nodules - genetics; Multiple Pulmonary Nodules - pathology; Mutation; Nodules; p53 Protein; Patients; Point mutation; Proto-Oncogene Proteins p21(ras) - genetics; Retrospective Studies; Subgroups; TP53; Tumor growth; Tumor proteins; Tumor Suppressor Protein p53 - genetics; KRAS; Tumor growth; Early pulmonary nodules; TP53
• ISSN: 1749-8090; 1749-8090
• DOI: 10.1186/s13019-024-02927-0

The purpose of this study is to investigate whether gene mutations can lead to the growth of malignant pulmonary nodules.
Retrospective analysis was conducted on patients with pulmonary nodules at Hebei Provincial People's Hospital, collecting basic clinical information such as gender, age, BMI, and hematological indicators. According to the inclusion and exclusion criteria, 85 patients with malignant pulmonary nodules were selected for screening, and gene mutation testing was performed on all patient tissues to explore the relationship between gene mutations and the growth of malignant pulmonary nodules.
There is a correlation between KRAS and TP53 gene mutations and the growth of pulmonary nodules (P < 0.05), while there is a correlation between KRAS and TP53 gene mutations and the growth of pulmonary nodules in the subgroup of invasive malignant pulmonary nodules (P < 0.05).
Mutations in the TP53 gene can lead to the growth of malignant pulmonary nodules and are correlated with the degree of invasion of malignant pulmonary nodules.