(Stereotactic) radiosurgery XIX: spinal radiosurgery - two year experience in a UK centre

• Published in: British journal of neurosurgery Vol. 26; no. 1; pp. 53 - 58
• Main Authors: Martin, A.G.R., Cowley, I.R., Taylor, B.A., Cassoni, A.M., Landau, D.B., Plowman, P.N.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01-02-2012; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Adult; Aged; Aged, 80 and over; Back surgery; CyberKnife; Female; Humans; Male; Middle Aged; Pain management; Postoperative Complications - etiology; Radiation therapy; radiosurgery; Radiosurgery - adverse effects; Radiosurgery - methods; Radiotherapy Dosage; Spinal cord injuries; Spinal Neoplasms - secondary; Spinal Neoplasms - surgery; spinal tumour; spine; stereotactic body radiotherapy; Surgical outcomes; Treatment Outcome; United Kingdom > UK
• ISSN: 0268-8697; 1360-046X
• DOI: 10.3109/02688697.2011.603857

Abstract
Introduction. Modern radiotherapy image guidance enables the treatment of extracranial targets with the required accuracy for safe delivery of radiosurgical treatments. The first two years' experience of spinal radiosurgery in a UK radiotherapy centre is reported. Materials and methods. Patients with primary or metastatic spinal lesions were treated using the CyberKnife stereotactic radiotherapy system. Xsight Spine (fiducial-free) tumour tracking software was used in all cases. Treatment was delivered using either a single or a three-fraction schedule, between February 2009 and March 2011. Results. Fifty-three spinal lesions were treated, comprising 14 primary lesions in 12 patients, and 39 metastases in 29 patients. The prescription dose ranged from 8 to 30 Gy in 1-3 fractions. Fifty-nine percent of patients experienced no acute side effects from treatment. There were three cases of acute grade 3 back or nerve root pain, all of which responded to a short course of oral corticosteroids. At a median follow-up of 11.1 months, local control and overall survival were 91 and 65%, respectively. Pain improvement was seen in 75% of symptomatic metastases at 6 months post treatment. Conclusions. Early UK experience confirms that radiosurgery is well tolerated with excellent local control rates. Longer-term prospective data are needed to clarify the role of spinal radiosurgery for patients in this country.