Detection of early lung cancer using low dose Photofrin II

Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin ph...

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Bibliographic Details
Published in:	Chest Vol. 97; no. 2; p. 333
Main Authors:	Lam, S, Palcic, B, McLean, D, Hung, J, Korbelik, M, Profio, A E
Format:	Journal Article
Language:	English
Published:	United States 01-02-1990
Subjects:	Aged Bronchoscopy - methods Carcinoma in Situ - diagnosis Carcinoma, Squamous Cell - diagnosis Dihematoporphyrin Ether Fiber Optic Technology - instrumentation Fluorescence Hematoporphyrins - administration & dosage Humans Lasers Lung Neoplasms - diagnosis Male Middle Aged Photosensitivity Disorders - diagnosis Skin Tests
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Summary:	Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm2 visible light on skin photosensitivity test.
ISSN:	0012-3692
DOI:	10.1378/chest.97.2.333