An automated system for fast transfer and injection of hyperpolarized solutions

• Published in: Journal of Magnetic Resonance Open Vol. 8-9; p. 100017
• Main Authors: Ceillier, Morgan, Cala, Olivier, El Daraï, Théo, Cousin, Samuel F., Stern, Quentin, Guibert, Sylvie, Elliott, Stuart J., Bornet, Aurélien, Vuichoud, Basile, Milani, Jonas, Pages, Christophe, Eshchenko, Dmitry, Kempf, James G., Jose, Catherine, Lambert, Simon A., Jannin, Sami
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-12-2021; Elsevier
• Subjects: Analytical chemistry; Chemical Sciences; dDNP; Dissolution; Hyperpolarization; Instrumentation; NMR; Transfer; Transfer; Instrumentation; NMR; dDNP; Dissolution; Hyperpolarization
• ISSN: 2666-4410; 2666-4410
• DOI: 10.1016/j.jmro.2021.100017

•We report the design of a home built dissolution, transfer and injection system for dDNP.•It provides a way to transfer hyperpolarized solutions over 10 m at a speed of 5 m per second.•We obtain sub Hz resolution within 5 s after injection.
Dissolution dynamic nuclear polarization (dDNP) has become a hyperpolarization method of choice for enhancing nuclear magnetic resonance (NMR) signals. Nuclear spins are polarized in solid frozen samples (in a so-called polarizer) that are subsequently dissolved and transferred to an NMR spectrometer for high sensitivity detection. One of the critical challenges of dDNP is that it requires both a fast transfer to limit nuclear spin relaxation losses as well as stability to guarantee high resolution (no bubbles nor turbulences). Here we describe the design, construction and performances of such a transfer and injection system, that features a 5 m/s speed and sub-Hz spectral resolution upon arrival at the detection spot. We demonstrate the use of such a system for inter-magnet distances of up to 10 m.
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