Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals

• Published in: Human Immunology Vol. 64; no. 7; pp. 729 - 732
• Main Authors: Williams, Fionnuala, Maxwell, Lynn D, Halfpenny, Iris A, Meenagh, Ashley, Sleator, Carole, Curran, Martin D, Middleton, Derek
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-07-2003
• Subjects: Alleles; Gene Dosage; Gene Duplication; Gene Expression; Humans; Killer Cells, Natural - immunology; KIR 2DL4; KIR 3DL/S1; Polymerase Chain Reaction; Receptors, Immunologic - genetics; Receptors, KIR; Receptors, KIR2DL4; Receptors, KIR3DL1; Receptors, KIR3DS1; Sequence Analysis; SSOP; KIR 2DL4; gene duplication; KIR 3DL/S1; SSOP
• ISSN: 0198-8859; 1879-1166; 1365-2567
• DOI: 10.1016/S0198-8859(03)00089-2

Multiple copies of the killer immunoglobulin-like receptor gene, 3DL/S1, have been identified in certain individuals. Additionally, allele determination of the killer immunoglobulin-like receptor gene (KIR), 2DL4, has identified three alleles of this gene present in these same individuals. This event has been confirmed by isolating three distinct KIR2DL4 allele clones in each individual, which sequenced as the alleles identified by the allele identification technique. It is our assumption that an unequal crossover event has occurred between differing KIR haplotypes resulting in the duplication of the 2DL4, 3DS1/3DL1 genes on the newly formed haplotype(s).