Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer

• Published in: Nutrients Vol. 12; no. 5; p. 1473
• Main Authors: Hagihara, Keisuke, Kajimoto, Katsufumi, Osaga, Satoshi, Nagai, Naoko, Shimosegawa, Eku, Nakata, Hideyuki, Saito, Hitomi, Nakano, Mai, Takeuchi, Mariko, Kanki, Hideaki, Kagitani-Shimono, Kuriko, Kijima, Takashi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 19-05-2020; MDPI AG
• Subjects: Adult; Aged; Blood Glucose - analysis; cancer; Diet, Ketogenic - methods; Diet, Ketogenic - mortality; Fasting - blood; Female; Humans; Insulin - blood; ketogenic diet; Ketone Bodies - blood; Male; Middle Aged; Neoplasm Staging; Neoplasms - blood; Neoplasms - diet therapy; Neoplasms - mortality; PET-CT; Positron Emission Tomography Computed Tomography; Survival Rate; Time Factors; Treatment Outcome; ketogenic diet; PET-CT; cancer
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12051473

A ketogenic diet is expected to be an effective support therapy for patients with cancer, but the degree and duration of carbohydrate restriction are unclear. We performed a case series study of a new ketogenic diet regimen in patients with different types of stage IV cancer. Carbohydrates were restricted to 10 g/day during week one, 20 g/day from week two for three months, and 30 g/day thereafter. A total of 55 patients participated in the study, and data from 37 patients administered the ketogenic diet for three months were analyzed. No severe adverse events associated with the diet were observed. Total ketone bodies increased significantly, and both fasting blood sugar and insulin levels were suppressed significantly for three months after completion of the study. Five patients showed a partial response on Positron emission tomography-computed tomography (PET-CT) at three months. Three and seven patients showed complete and partial responses, respectively at one year. Median survival was 32.2 (maximum: 80.1) months, and the three-year survival rate was 44.5%. After three months on the ketogenic diet, the serum Alb, BS, and CRP (ABC) score could be used to stratify the patients into groups with significantly different survival rates (
< 0.001, log-rank test). Our ketogenic diet regimen is considered to be a promising support therapy for patients with different types of advanced cancer.