Presepsin (sCD14-ST) in preoperative diagnosis of abdominal sepsis

• Published in: Clinical chemistry and laboratory medicine Vol. 51; no. 10; p. 2053
• Main Authors: Vodnik, Tatjana, Kaljevic, Goran, Tadic, Tanja, Majkic-Singh, Nada
• Format: Journal Article
• Language: English
• Published: Germany 01-10-2013
• Subjects: Abdomen - microbiology; Abdomen - pathology; Adult; Aged; Aged, 80 and over; Area Under Curve; Biomarkers - blood; C-Reactive Protein - metabolism; Calcitonin - blood; Calcitonin Gene-Related Peptide; Diagnosis, Differential; Female; Humans; Immunoenzyme Techniques; Lipopolysaccharide Receptors - blood; Luminescent Measurements; Male; Middle Aged; Protein Isoforms - blood; Protein Precursors - blood; ROC Curve; Sepsis - blood; Sepsis - diagnosis; Sepsis - microbiology; Solubility; Systemic Inflammatory Response Syndrome - blood; Systemic Inflammatory Response Syndrome - diagnosis; Systemic Inflammatory Response Syndrome - microbiology
• ISSN: 1437-4331
• DOI: 10.1515/cclm-2013-0061

The aim of the study was to identify the diagnostic significance of presepsin in acute abdominal conditions and also to examine the correlation between presepsin, procalcitonin (PCT) and other parameters.
To detect presepsin we used a new rapid method based on a chemiluminescent enzyme immunoassay. The clinical usefulness of presepsin to differentiate bacterial and non-bacterial infection [including systemic inflammation response syndrome (SIRS)] was studied and compared with PCT, C-reactive protein (CRP) and white blood cells (WBC).
The presepsin values in different conditions were (mean±standard deviation): healthy group (n=70) 258.7±92.53 pg/mL; SIRS (n=30) 430.0±141.33 pg/mL; sepsis (n=30) 1508.3±866.6 pg/mL. The presepsin values were significantly higher in patients with sepsis than the SIRS group (p<0.0001, Mann-Whitney U-test). The area under the receiver operating characteristics (ROC) curve (AUC) for discriminating of the SIRS from the sepsis patients was 0.996 for presepsin and it was greater than the AUC of PCT (0.912), CRP (0.857) or WBC (0.777).
The ROC curve of the SIRS patient without infection and the sepsis patient showed that the presepsin concentration was a significantly sensitive indicator of sepsis and useful marker for the rapid diagnosis of sepsis.