Complement-endothelial cell interactions: pathophysiological implications

The function of the endothelial cells can be modulated by humoral factors present in the circulation and in the extravascular fluid, including proteins of the complement system. This review examines the multiple interactions between the complement system and the endothelial cells and their functiona...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular Immunology Vol. 36; no. 4; pp. 261 - 268
Main Authors:	Tedesco, F, Fischetti, F, Pausa, M, Dobrina, A, Sim, R.B, Daha, M.R
Format:	Book Review Journal Article
Language:	English
Published:	England Elsevier Ltd 01-03-1999
Subjects:	Animals Cell Communication - immunology Complement System Proteins - physiology Endothelium, Vascular - cytology Endothelium, Vascular - immunology Endothelium, Vascular - physiopathology Humans
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The function of the endothelial cells can be modulated by humoral factors present in the circulation and in the extravascular fluid, including proteins of the complement system. This review examines the multiple interactions between the complement system and the endothelial cells and their functional consequences on inflammation, coagulation and regulation of vascular tone. The implications of these interactions in the induction and progression of the vascular lesions occurring in atherosclerosis, ischemia/reperfusion and xenotransplantation and the possible therapeutic approaches in terms of complement regulation are also discussed.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0161-5890 1872-9142
DOI:	10.1016/S0161-5890(99)90054-8