Diagnosis and treatment of bacteremia and endocarditis due to Staphylococcus aureus . A clinical guideline from the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC)

Abstract Both bacteremia and infective endocarditis caused by Staphylococcus aureus are common and severe diseases. The prognosis may darken not infrequently, especially in the presence of intracardiac devices or methicillin-resistance. Indeed, the optimization of the antimicrobial therapy is a key...

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Published in:Enfermedades infecciosas y microbiologia clinica Vol. 33; no. 9; pp. 625.e1 - 625.e23
Main Authors: Gudiol, Francesc, Aguado, José María, Almirante, Benito, Bouza, Emilio, Cercenado, Emilia, Domínguez, M. Ángeles, Gasch, Oriol, Lora-Tamayo, Jaime, Miró, José M, Palomar, Mercedes, Pascual, Alvaro, Pericas, Juan M, Pujol, Miquel, Rodríguez-Baño, Jesús, Shaw, Evelyn, Soriano, Alex, Vallés, Jordi
Format: Journal Article
Language:English
Published: Spain Elsevier España, S.L.U 01-11-2015
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Abstract Abstract Both bacteremia and infective endocarditis caused by Staphylococcus aureus are common and severe diseases. The prognosis may darken not infrequently, especially in the presence of intracardiac devices or methicillin-resistance. Indeed, the optimization of the antimicrobial therapy is a key step in the outcome of these infections. The high rates of treatment failure and the increasing interest in the influence of vancomycin susceptibility in the outcome of infections caused by both methicillin-susceptible and -resistant isolates has led to the research of novel therapeutic schemes. Specifically, the interest raised in recent years on the new antimicrobials with activity against methicillin-resistant staphylococci has been also extended to infections caused by susceptible strains, which still carry the most important burden of infection. Recent clinical and experimental research has focused in the activity of new combinations of antimicrobials, their indication and role still being debatable. Also, the impact of an appropriate empirical antimicrobial treatment has acquired relevance in recent years. Finally, it is noteworthy the impact of the implementation of a systematic bundle of measures for improving the outcome. The aim of this clinical guideline is to provide an ensemble of recommendations in order to improve the treatment and prognosis of bacteremia and infective endocarditis caused by S. aureus , in accordance to the latest evidence published.
AbstractList Both bacteremia and infective endocarditis caused by Staphylococcus aureus are common and severe diseases. The prognosis may darken not infrequently, especially in the presence of intracardiac devices or methicillin-resistance. Indeed, the optimization of the antimicrobial therapy is a key step in the outcome of these infections. The high rates of treatment failure and the increasing interest in the influence of vancomycin susceptibility in the outcome of infections caused by both methicillin-susceptible and -resistant isolates has led to the research of novel therapeutic schemes. Specifically, the interest raised in recent years on the new antimicrobials with activity against methicillin-resistant staphylococci has been also extended to infections caused by susceptible strains, which still carry the most important burden of infection. Recent clinical and experimental research has focused in the activity of new combinations of antimicrobials, their indication and role still being debatable. Also, the impact of an appropriate empirical antimicrobial treatment has acquired relevance in recent years. Finally, it is noteworthy the impact of the implementation of a systematic bundle of measures for improving the outcome. The aim of this clinical guideline is to provide an ensemble of recommendations in order to improve the treatment and prognosis of bacteremia and infective endocarditis caused by S. aureus, in accordance to the latest evidence published.
Both bacteremia and infective endocarditis caused by Staphylococcus aureus are common and severe diseases. The prognosis may darken not infrequently, especially in the presence of intracardiac devices or methicillin-resistance. Indeed, the optimization of the antimicrobial therapy is a key step in the outcome of these infections. The high rates of treatment failure and the increasing interest in the influence of vancomycin susceptibility in the outcome of infections caused by both methicillin-susceptible and -resistant isolates has led to the research of novel therapeutic schemes. Specifically, the interest raised in recent years on the new antimicrobials with activity against methicillin-resistant staphylococci has been also extended to infections caused by susceptible strains, which still carry the most important burden of infection. Recent clinical and experimental research has focused in the activity of new combinations of antimicrobials, their indication and role still being debatable. Also, the impact of an appropriate empirical antimicrobial treatment has acquired relevance in recent years. Finally, it is noteworthy the impact of the implementation of a systematic bundle of measures for improving the outcome. The aim of this clinical guideline is to provide an ensemble of recommendations in order to improve the treatment and prognosis of bacteremia and infective endocarditis caused by S. aureus, in accordance to the latest evidence published. Tanto la bacteriemia como la endocarditis infecciosa causada por Staphylococcus aureus son infecciones graves y frecuentes. El pronóstico puede verse ensombrecido por la presencia de dispositivos cardíacos o por la resistencia a meticilina. La optimización del tratamiento antimicrobiano es clave en los resultados. Las considerables tasas de fracaso terapéutico y la influencia de la susceptibilidad a vancomicina en el pronóstico, tanto de los episodios causados por cepas resistentes como sensibles a meticilina, ha conducido a la investigación de nuevos esquemas terapéuticos. Específicamente, el interés que en los últimos años han generado los nuevos antibióticos con actividad frente a cepas resistentes a meticilina se ha extendido a las cepas sensibles, que son aún responsables de la mayoría de los casos. Recientes estudios en el ámbito clínico y experimental se han centrado en la actividad de nuevas combinaciones, cuyo papel e indicación clínicas son aún objeto de debate. Por otro lado, la importancia de un tratamiento antibiótico empírico precoz y adecuado ha cobrado interés en los últimos años. Finalmente, cabe destacar el impacto que la instauración de un conjunto sistemático de medidas en el manejo de la bacteriemia estafilocócica tiene en el pronóstico global de la infección. Esta guía clínica reúne un conjunto de recomendaciones a la luz de la última evidencia científica, con el objeto de mejorar el tratamiento y pronóstico de la bacteriemia y endocarditis infecciosa causada por S. aureus.
Abstract Both bacteremia and infective endocarditis caused by Staphylococcus aureus are common and severe diseases. The prognosis may darken not infrequently, especially in the presence of intracardiac devices or methicillin-resistance. Indeed, the optimization of the antimicrobial therapy is a key step in the outcome of these infections. The high rates of treatment failure and the increasing interest in the influence of vancomycin susceptibility in the outcome of infections caused by both methicillin-susceptible and -resistant isolates has led to the research of novel therapeutic schemes. Specifically, the interest raised in recent years on the new antimicrobials with activity against methicillin-resistant staphylococci has been also extended to infections caused by susceptible strains, which still carry the most important burden of infection. Recent clinical and experimental research has focused in the activity of new combinations of antimicrobials, their indication and role still being debatable. Also, the impact of an appropriate empirical antimicrobial treatment has acquired relevance in recent years. Finally, it is noteworthy the impact of the implementation of a systematic bundle of measures for improving the outcome. The aim of this clinical guideline is to provide an ensemble of recommendations in order to improve the treatment and prognosis of bacteremia and infective endocarditis caused by S. aureus , in accordance to the latest evidence published.
Author Shaw, Evelyn
Miró, José M
Gasch, Oriol
Rodríguez-Baño, Jesús
Vallés, Jordi
Gudiol, Francesc
Pericas, Juan M
Lora-Tamayo, Jaime
Domínguez, M. Ángeles
Soriano, Alex
Pujol, Miquel
Cercenado, Emilia
Almirante, Benito
Pascual, Alvaro
Bouza, Emilio
Palomar, Mercedes
Aguado, José María
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Copyright Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica
2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica
Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.
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– notice: 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica
– notice: Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.
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DocumentTitleAlternate Diagnóstico y el tratamiento de la bacteriemia y endocarditis por Staphylococcus aureus. Una guía de práctica clínica de la Sociedad Española de Microbiología Clínica y Enfermedades Infecciosas (SEIMC)
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Issue 9
Keywords Methicillin-susceptible
Bacteriemia
Resistente a meticilina
Methicillin-resistant
Infective endocarditis
Clinical guidelines
Sensible a meticilina
Endocarditis infecciosa
Bacteremia
Staphylococcus aureus
Documento de consenso
Language English
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elsevier_clinicalkeyesjournals_1_s2_0_S0213005X15001251
PublicationCentury 2000
PublicationDate 2015-11-01
PublicationDateYYYYMMDD 2015-11-01
PublicationDate_xml – month: 11
  year: 2015
  text: 2015-11-01
  day: 01
PublicationDecade 2010
PublicationPlace Spain
PublicationPlace_xml – name: Spain
PublicationTitle Enfermedades infecciosas y microbiologia clinica
PublicationTitleAlternate Enferm Infecc Microbiol Clin
PublicationYear 2015
Publisher Elsevier España, S.L.U
Publisher_xml – name: Elsevier España, S.L.U
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Snippet Abstract Both bacteremia and infective endocarditis caused by Staphylococcus aureus are common and severe diseases. The prognosis may darken not infrequently,...
Both bacteremia and infective endocarditis caused by Staphylococcus aureus are common and severe diseases. The prognosis may darken not infrequently,...
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SubjectTerms Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacteremia
Bacteremia - diagnosis
Bacteremia - drug therapy
Bacteremia - microbiology
Bacteriemia
Clinical guidelines
Cross Infection - diagnosis
Cross Infection - drug therapy
Cross Infection - microbiology
Disease Management
Documento de consenso
Endocarditis infecciosa
Endocarditis, Bacterial - diagnosis
Endocarditis, Bacterial - drug therapy
Endocarditis, Bacterial - microbiology
Endocarditis, Bacterial - surgery
Humans
Infectious Disease
Infective endocarditis
Methicillin-resistant
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Methicillin-susceptible
Microbial Sensitivity Tests
Polymerase Chain Reaction
Population Surveillance
Resistente a meticilina
Sensible a meticilina
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Standard of Care
Staphylococcal Infections - diagnosis
Staphylococcal Infections - diagnostic imaging
Staphylococcal Infections - drug therapy
Staphylococcus aureus
Title Diagnosis and treatment of bacteremia and endocarditis due to Staphylococcus aureus . A clinical guideline from the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC)
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https://dx.doi.org/10.1016/j.eimc.2015.03.015
https://www.ncbi.nlm.nih.gov/pubmed/25937457
Volume 33
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