The "Click" Reaction Involving Metal Azides, Metal Alkynes, or Both: An Exploration into Multimetal Structures

• Published in: Chemistry : a European journal Vol. 19; no. 11; pp. 3534 - 3541
• Main Authors: Casarrubios, Luis, de la Torre, María C., Sierra, Miguel A.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 11-03-2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Alkynes; Alkynes - chemistry; Azides - chemistry; Catalysis; Chemical reactions; Chemistry; Click Chemistry; copper; Copper - chemistry; Cyclization; cycloaddition; Dendrimers; Derivatives; Exploration; metal alkynes; metal azides; Metalorganic compounds; Molecular Structure; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Polymers; polymetallic complexes; Sketches
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201204596

CuI‐catalyzed 1,3‐cycloaddition of azides and alkynes (CuAAC) is one of the most powerful synthetic methodologies known. However, its use to prepare well‐defined multimetallic structures is underdeveloped. Apart from the applications of this reaction to anchor different organometallic reagents to surfaces, polymers, and dendrimers, only isolated examples of CuAAC with metal–η1‐alkyne and metal–azide complexes to prepare multimetal entities have been reported. This concept sketches the potential of these reactions not only to prepare “a la carte” multimetal 1,2,3‐triazole derivatives, but also to discover new and unprecedented reactions.
Metals take over the click brigade: The use of CuI‐catalyzed 1,3‐cycloaddition of azides and alkynes (CuAAC) to prepare well‐defined multimetallic structures is underdeveloped. Only isolated examples of the CuAAC with metal–η1‐alkyne and metal–azide complexes to prepare multimetal entities have been reported. This concept sketches the potential of these reactions not only to prepare “a la carte” multimetal 1,2,3‐triazole derivatives, but also to discover new and unprecedented reactions.