Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles

Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto‐oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescen...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 51; no. 42; pp. 10556 - 10560
Main Authors:	Agostini, Alessandro, Mondragón, Laura, Bernardos, Andrea, Martínez-Máñez, Ramón, Marcos, M. Dolores, Sancenón, Félix, Soto, Juan, Costero, Ana, Manguan-García, Cristina, Perona, Rosario, Moreno-Torres, Marta, Aparicio-Sanchis, Rafael, Murguía, José Ramón
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 15-10-2012 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Age beta-Galactosidase - chemistry beta-Galactosidase - metabolism Biomarkers Capping Cell Line, Tumor Cellular Senescence Controlled release drug delivery Drug Delivery Systems - instrumentation Drug Delivery Systems - methods dyskeratosis congenita Fluorescent Dyes - administration & dosage Fluorescent Dyes - chemistry gated mesoporous materials Humans Learning Nanoparticles Nanoparticles - chemistry Porosity Rhodamines - administration & dosage Rhodamines - chemistry Silicon dioxide Silicon Dioxide - chemistry
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Summary:	Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto‐oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence‐associated β‐galactosidase (SA‐β‐gal), and releases the cargo upon entry into SA‐β‐gal expressing cells.
Bibliography:	ark:/67375/WNG-GD3HLS2C-P Spanish Government - No. MAT2009-14564-C04; No. FIS PI11-0949 Fundación Ramón Areces Universidad Politécnica de Valencia - No. UPV PAID-05-09 istex:43A8F5FB5B8760CFFDBF69B8FE391E74503915A2 ArticleID:ANIE201204663 Generalitat Valencia - No. PROMETEO/2009/016 We thank the Spanish Government (projects MAT2009-14564-C04 and FIS PI11-0949) the Generalitat Valencia (project PROMETEO/2009/016), and the Universidad Politécnica de Valencia (UPV PAID-05-09) for support. We thank Fundación Ramón Areces for support. C.M.-G. is supported by CIBERER. L.M. thanks the Generalitat Valenciana for her VALI+D postdoctoral contract. These authors contributed equally to this work. We thank the Spanish Government (projects MAT2009‐14564‐C04 and FIS PI11‐0949) the Generalitat Valencia (project PROMETEO/2009/016), and the Universidad Politécnica de Valencia (UPV PAID‐05‐09) for support. We thank Fundación Ramón Areces for support. C.M.‐G. is supported by CIBERER. L.M. thanks the Generalitat Valenciana for her VALI+D postdoctoral contract. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201204663