The role of KSRP in mRNA decay and microRNA precursor maturation

• Published in: Wiley interdisciplinary reviews. RNA Vol. 1; no. 2; pp. 230 - 239
• Main Authors: Gherzi, Roberto, Chen, Ching-Yi, Trabucchi, Michele, Ramos, Andres, Briata, Paola
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01-09-2010; Wiley Subscription Services, Inc
• Subjects: Animals; Cell proliferation; Humans; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Models, Biological; mRNA turnover; Nucleic acids; Proteins; RNA Precursors - metabolism; RNA Processing, Post-Transcriptional - genetics; RNA Stability - genetics; RNA-binding protein; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; RNA-Binding Proteins - physiology; Splicing; Trans-Activators - genetics; Trans-Activators - metabolism; Trans-Activators - physiology
• ISSN: 1757-7004; 1757-7012
• DOI: 10.1002/wrna.2

KH‐type splicing regulatory protein (KSRP)/FBP2, a single‐strand nucleic acid binding protein originally identified as both an RNA‐binding protein and a transcription factor, affects RNA fates at multiple levels. In this review we will discuss the ability of KSRP to (1) promote decay of labile mRNAs by interacting with some components of the mRNA decay machinery and (2) favor the maturation of a select group of microRNA precursors. We also discuss how its peculiar modular structure allows KSRP to specifically interact with a wide spectrum of RNA sequences and how post‐translational modifications influence KSRP functions in cell proliferation and differentiation. Copyright © 2010 John Wiley & Sons, Ltd.
This article is categorized under:
RNA Evolution and Genomics > Ribonomics
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
RNA Turnover and Surveillance > Regulation of RNA Stability