Mineral Intake and Cardiovascular Disease, Cancer, and All-Cause Mortality: Findings from the Golestan Cohort Study

• Published in: Nutrients Vol. 16; no. 3; p. 344
• Main Authors: Yazdanpanah, Mohammad Hosein, Sharafkhah, Maryam, Poustchi, Hossein, Etemadi, Arash, Sheikh, Mahdi, Kamangar, Farin, Pourshams, Akram, Boffetta, Paolo, Dawsey, Sanford M, Abnet, Christian C, Malekzadeh, Reza, Hashemian, Maryam
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-01-2024
• Subjects: Alcohol; Analysis; Body mass index; Cancer; Cardiovascular disease; Cardiovascular diseases; Cohort analysis; Copper; dietary mineral intake; Education; Energy; Ethnicity; Exercise; Food; Health aspects; Hypertension; Iran; Lifestyles; Marital status; Mortality; Oncology, Experimental; Population; Potassium; Questionnaires; Risk factors; Selenium; Smoking; Middle East; Iran; China; United States > US; mortality; cardiovascular disease; cancer; Iran; dietary mineral intake
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16030344

Associations between mineral intake and mortality in non-Western countries have not been studied adequately. This study evaluated these associations in the Golestan Cohort Study, featuring a Middle Eastern population. The mineral intake was estimated from the baseline food frequency questionnaire, adjusted by using the nutrient density method, and divided into quintiles. We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the mortality. We analyzed 41,863 subjects with a mean age of 51.46 ± 8.73 years at the baseline. During 578,694 person-years of follow-up (median: 14.1 Years), 7217 deaths were recorded. Dietary calcium intake was inversely associated with the all-cause mortality (HR
= 0.91, 95%CI = 0.85-0.99). We observed significant associations between calcium (HR
= 0.82, 95% CI = 0.73-0.93), copper (HR
= 1.11, 95% CI = 0.99-1.26), and selenium intake (HR
= 1.14, 95% CI = 1.01-1.29) and CVD mortality. Dietary phosphorus (HR
= 0.81, 95%CI = 0.69-0.96) and copper intake (HR
= 0.84, 95%CI = 0.71-0.99) were inversely associated with cancer mortality. In this study within a Middle Eastern population, a higher dietary intake of calcium exhibited an inverse association with all-cause mortality. Furthermore, nuanced associations were observed in the cause-specific mortality, suggesting potential avenues for dietary interventions and emphasizing the importance of considering dietary factors in public health strategies.