The contribution of intracortical inhibition to dynamics of orientation tuning in cat striate cortex neurons

• Published in: Neuroscience Vol. 84; no. 1; pp. 11 - 23
• Main Authors: Shevelev, I.A, Eysel, U.T, Lazareva, N.A, Sharaev, G.A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01-05-1998
• Subjects: Animals; bicuculline; Bicuculline - pharmacology; cat; Cats; Cerebral Cortex - physiology; GABA Antagonists - pharmacology; inhibition; Neural Inhibition - drug effects; Neural Inhibition - physiology; Neurons - physiology; Orientation - physiology; orientation tuning; receptive fields; Time Factors; visual cortex; Visual Cortex - cytology; Visual Cortex - physiology; orientation tuning; PSTH, peri-stimulus time histogram; visual cortex; bicuculline; PSP, postsynaptic potential; cat; C-cell, cell with complex receptive field; S-cell, cell with simple RF; receptive fields; inhibition; V1, area 17 of the visual cortex; RF, receptive field
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/S0306-4522(97)00363-1

Orientation tuning of some neurons in cat visual cortex (area 17) revealed successive shifts of the preferred orientation and widening of tuning in time during the first 150
ms after onset of a flashing light bar. The mechanisms of these dynamics and the possible role of intracortical inhibition are still under discussion. In this study we analysed the dynamics using the time slice method before and during blockade of GABAergic inhibition by microiontophoretic application of bicuculline and observed two main types of neuronal behaviour. The first group of neurons (39 of 68 units or 57.4%) with relatively sharp tuning and absence or relatively small shifts of preferred orientation under control conditions increased or developed this shift during bicuculline application. Changes in tuning were observed between 30 and 150
ms after stimulus onset when inhibition was blocked. Neurons of the second group (29 units or 42.6% of cases) displayed pronounced shifts of preferred orientation under control conditions which was typically diminished or lost during blockade of inhibition.
The results indicate different contributions of intracortical inhibition to different neurons distinguishing by stability or time dependence of their orientation preference during normal response generation. In one group of striate cells orientation tuning was kept narrow and constant in time by intracortical inhibition, while in another group orientation tuning dynamics are induced by inhibitory mechanisms.