Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 11; p. 2576
• Main Authors: Baptista, Filipa, Paié-Ribeiro, Jessica, Almeida, Mariana, Barros, Ana Novo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30-05-2024; MDPI
• Subjects: Acids; Analysis; Animals; Antioxidants; Atherosclerosis; Biological Availability; Cardiovascular disease; Chronic kidney failure; chronic liver diseases; Complications and side effects; Development and progression; diabetes; Dietary Supplements; Flavonoids; Functional foods; herbal medicine; Humans; Inflammation; Kidney diseases; nephrotoxicity; Oxidative stress; Phenols - chemistry; Phenols - pharmacology; Phenols - therapeutic use; Phytochemicals; Public health; renal injury; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - metabolism; Review; Seeds; Type 2 diabetes; chronic liver diseases; nephrotoxicity; diabetes; herbal medicine; renal injury
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29112576

Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds in managing CKD and its complications. By examining the existing research, we highlight their diverse biological activities and potential to combat CKD-related issues. We analyze the nutritional benefits, bioavailability, and safety profile of these compounds. While the clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, and potential side effects. Further research is crucial to validate the therapeutic efficacy of phenolic compounds for CKD. We advocate for continued exploration of their innovative applications in food, pharmaceuticals, and nutraceuticals. This review aims to catalyze the scientific community's efforts to leverage phenolic compounds against CKD-related challenges.