Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports

• Published in: BMC research notes Vol. 10; no. 1; p. 52
• Main Authors: Santiago, Fábio, Lima, Simone, Pinheiro, Tayná, Silvestre, Rafaele Tavares, Otero, Ubirani Barros, Tabalipa, Marianne Medeiros, Kosyakova, Nadezda, Ornellas, Maria Helena, Liehr, Thomas, Alves, Gilda
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18-01-2017; BioMed Central
• Subjects: Abortion, Spontaneous; Adult; Benzene; Benzene - poisoning; Case Report; Case studies; Chromosome Aberrations; Chromosome Painting; Chromosomes - ultrastructure; Female; Gene Rearrangement; Health aspects; Humans; In Situ Hybridization, Fluorescence; Killer Cells, Natural - cytology; Occupational Exposure - adverse effects; Officials and employees; Service stations (Motor vehicles); Services industry workers; Time Factors; Toluene - poisoning; Xylenes - poisoning; Brazil; Painting chromosome; Natural killer; Benzene; Toluene; Cytogenetic; Xylene
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-016-2369-8

Brazilian gas station workers are chronically exposed to benzene, toluene, xylene (BTX) during their working time. Describe below two cases of latin female gas station workers with benzene poisoning symptoms and miscarriage history.
In both cases were identified complex chromosomal rearrangements (CCR) with fluorescence in situ hybridization, applied to whole chromosome paints by chromosomes 1, 2 and 4. The lower natural killer cell (NK) cells have also been observed in cases correspondents, especially the rare type of NK (NKbright) in their peripheral blood cells.
It is known that acquired chromosomal aberrations are positively correlated with cancer and reproductive risk. In concordance, lower NK cytotoxicity increases the risk for cancer, as well. Thus, this is the first study providing hints on a possible causative relation of lower NK cytotoxicity and increase rates of chromosomal rearrangements including CCRs.