Characteristics of penile cancer in Japan: An analysis of nationwide hospital‐based cancer registry data

• Published in: International journal of urology Vol. 27; no. 6; pp. 538 - 542
• Main Authors: Tanaka, Ken, Kandori, Shuya, Nitta, Satoshi, Chihara, Ichiro, Kojo, Kosuke, Nagumo, Yoshiyuki, Kimura, Tomokazu, Kojima, Takahiro, Kawai, Koji, Okuyama, Ayako, Higashi, Takahiro, Nishiyama, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01-06-2020
• Subjects: Adenocarcinoma; Adenosquamous; Age composition; Aged; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - therapy; Chemotherapy; Circumcision; Diagnosis; Genital cancers; Geriatrics; Health risk assessment; Hospitals; hospital‐based cancer registry; Human papillomavirus; Humans; Japan - epidemiology; Lymph nodes; Male; Metastases; Metastasis; Middle Aged; Patients; penile cancer; penile neoplasm; Penile Neoplasms - epidemiology; Penile Neoplasms - therapy; Penis; Registries; Squamous cell carcinoma; treatment; Tumors; Japan; treatment; hospital-based cancer registry; penile cancer; penile neoplasm; squamous cell carcinoma
• ISSN: 0919-8172; 1442-2042
• DOI: 10.1111/iju.14247

Objectives
To investigate the clinical characteristics of patients with penile cancer in Japan using the nationwide hospital‐based cancer registry database.
Methods
Using hospital‐based cancer registry data, we described the distribution of age, pathology, tumor–node–metastases classification, and first‐course treatment in patients treated between 2012 and 2015. We compared the patterns of first‐line treatment between elderly and non‐elderly patients.
Results
A total of 1012 patients were diagnosed with squamous cell carcinoma among 1773 patients with penile tumors who registered under topography code C60. The median age at diagnosis was 74 years, and 85.9% of patients were aged >60 years. The most common pathology was usual‐type squamous cell carcinoma (91.9%), followed by verrucous carcinoma (5.0%), sarcomatoid carcinoma (1.1%), papillary carcinoma (0.7%), basaloid carcinoma (0.6%), adenosquamous carcinoma (0.4%), warty carcinoma (0.2%) and mixed carcinoma (0.1%). A total of 61.3% of patients were diagnosed with localized disease. In contrast, the proportions of patients with lymph node and distant metastases were 27.5% and 2.1% at diagnosis, respectively. The proportion of patients who were treated with chemotherapy as the first‐course treatment was significantly lower among elderly patients (≥80 years) with clinical stage III (27.6% vs 7.1%, P = 0.0312) and clinical stage IV (53.2% vs 14.3%, P = 0.0086).
Conclusions
Most penile cancer patients in Japan are diagnosed with usual‐type squamous cell carcinoma, and those with human papilloma virus‐related squamous cell carcinomas are <1%. Chemotherapy for advanced penile cancer is administered less in Japanese elderly (≥80 years) patients.