Immunotherapeutic strategies in breast cancer: A clinical update

Immunotherapy has been incorporated into the standard of care for a wide range of malignancies. The study of tumor‐infiltrating lymphocytes has emphasized the importance of the host antitumor immune response in the natural history of breast cancer. Recent clinical trials have used immunotherapeutic...

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Bibliographic Details
Published in:	Journal of surgical oncology Vol. 123; no. 3; pp. 710 - 717
Main Authors:	Zhang, Jennifer Q., Plitas, George
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-03-2021
Subjects:	Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - therapy checkpoint blockade Clinical outcomes Female Humans Immune Checkpoint Inhibitors - therapeutic use Immunotherapy Immunotherapy - methods Lymphocytes, Tumor-Infiltrating - immunology outcomes Randomized Controlled Trials as Topic checkpoint blockade outcomes immunotherapy
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Summary:	Immunotherapy has been incorporated into the standard of care for a wide range of malignancies. The study of tumor‐infiltrating lymphocytes has emphasized the importance of the host antitumor immune response in the natural history of breast cancer. Recent clinical trials have used immunotherapeutic approaches to augment this response and improve outcomes for patients with breast cancer. Here, we review several current clinical trial data that indicate checkpoint blockade may mediate clinically significant responses.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0022-4790 1096-9098
DOI:	10.1002/jso.26287