Assessment of Short‐term Blood Pressure Variability in Patients With Ascending Aortic Dilatation

• Published in: Clinical cardiology (Mahwah, N.J.) Vol. 38; no. 12; pp. 757 - 762
• Main Authors: Karataş, Mehmet Baran, İpek, Göktürk, Çanga, Yiğit, Güngör, Barış, Özcan, Kazim Serhan, Arugaslan, Emre, Günaydin, Zeki Yüksel, Durmuş, Gündüz, Onuk, Tolga, Kalenderoğlu, Koray, Akdeniz, Evliya, Bolca, Osman
• Format: Journal Article
• Language: English
• Published: New York Wiley Periodicals, Inc 01-12-2015; John Wiley & Sons, Inc
• Subjects: Adult; Aorta - pathology; Aortic Diseases - complications; Aortic Diseases - physiopathology; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory - methods; Clinical Investigations; Dilatation; Echocardiography; Female; Humans; Hypertension - complications; Hypertension - physiopathology; Male; Middle Aged; Retrospective Studies
• ISSN: 0160-9289; 1932-8737
• DOI: 10.1002/clc.22485

ABSTRACT
Background
Blood pressure variability (BPV) is a novel parameter related to adverse cardiovascular findings and events, especially in hypertensive patients. The aim of the present study was to investigate the relationship between short‐term BPV and ascending aortic dilatation (AAD).
Hypothesis
Hypertensive patients with AAD may exhibit higher short‐term BPV compared to hypertensive patients with normal diameter ascending aorta and BPV may be correlated with aortic sizes.
Methods
Seventy‐six hypertensive patients with AAD and 181 hypertensive patients with a normal‐diameter ascending aorta were retrospectively enrolled in the study. Clinical data, echocardiographic characteristics, and 24‐hour ambulatory blood pressure monitoring characteristics were compared between the 2 groups. Standard deviation (SD) and Δ of BP were used as parameters of BPV.
Results
Although 24‐hour mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were similar between the 2 groups, the SD of SBP and SD of DBP values were significantly higher in AAD patients (17.2 ± 6.8 vs 13.8 ± 3.5, P < 0.01; and 12.1 ± 5.1 vs 10.7 ± 3.1, P = 0.02, respectively). Daytime SD of SBP values were higher in AAD patients, whereas nighttime SD of SBP values did not differ between groups. In multivariate linear regression analysis, 24‐hour SD of SBP, 24‐hour Δ SBP, daytime SD of SBP, daytime Δ SBP, and left ventricular mass index were independently correlated with aortic size index.
Conclusions
Our study revealed higher levels of short‐term BPV in hypertensive patients with AAD. This conclusion warrants further study.