Pathologic Complete Remission after Preoperative High-Dose-Rate Brachytherapy in Patients with Operable Cervical Cancer: Preliminary Results of a Prospective Randomized Multicenter Study

• Published in: Pathology oncology research Vol. 21; no. 2; pp. 247 - 256
• Main Authors: Vízkeleti, Julia, Vereczkey, Ildikó, Fröhlich, Georgina, Varga, Szilvia, Horváth, Katalin, Pulay, Tamás, Pete, Imre, Nemeskéri, Csaba, Mayer, Árpád, Sipos, Norbert, Kásler, Miklós, Polgár, Csaba
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-04-2015; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Brachytherapy - methods; Cancer Research; Dose-Response Relationship, Radiation; Female; Follow-Up Studies; Gynecologic Surgical Procedures; Humans; Hungary; Immunology; Kaplan-Meier Estimate; Middle Aged; Oncology; Pathology; Preoperative Care - methods; Prospective Studies; Remission Induction - methods; Treatment Outcome; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - radiotherapy; Uterine Cervical Neoplasms - surgery; Hungary; Surgical margins; Preoperative brachytherapy; Pathologic complete remission; Cervical cancer
• ISSN: 1219-4956; 1532-2807
• DOI: 10.1007/s12253-014-9815-5

The role of preoperative intrauterine brachytherapy (BT) in the multidisciplinary treatment of early stage cervical carcinoma (ESCC) is controversial. In 2005, a prospective randomized multicenter study was initiated in Hungary in order to explore the potential advantages of preoperative high-dose-rate (HDR) BT. In this article we evaluate the efficiency of preoperative HDR BT by the rate of pathologic complete remission (pCR) in the first 185 patients enrolled in the study at the National Institute of Oncology and at the Uzsoki Municipal Cancer Center in collaboration with the 1st Department of Gynaecology and Obstetrics of Semmelweis University, Budapest, Hungary. In arm A, patients received 2x8Gy preoperative intracavitary HDR BT, while in arm B no preoperative treatment was given. In both arms patients underwent radical Wertheim (Piver III) hysterectomy. The pCR rate was 25.7% after preoperative HDR BT, while it was only 11.2% with surgery alone (p=0.03), in these cases the tumor was eliminated during the diagnostic excision or conisation. The rate of positive surgical margins was 1.5% after preoperative BT, while it was as high as 11.4% without preoperative RT (p=0.02). There was no significant difference in the local tumor control (LTC), distant metastases free survival (DMFS) and overall survival (OS) between the two arms. According to our preliminary results preoperative intracavitary HDR BT significantly increases the rate of pCR and decreases the rate of positive surgical margins in patients with ESCC. Longer follow-up is required to establish the possible impact of pCR on the ultimate LTC and OS.