Mixture of carbon aerogel with Pd–WO3 nanorods for amperometric determination of mesalazine

• Published in: Mikrochimica acta (1966) Vol. 188; no. 4; p. 135
• Main Authors: Rajkumar, Chellakannu, Choi, Jong-Ho, Kim, Haekyoung
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01-04-2021; Springer; Springer Nature B.V
• Subjects: Aerogels; Analytical Chemistry; Biological products; Carbon; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Electric properties; Electrical measurement; Electrocatalysts; Electrochemical oxidation; Electron transport; Mesalamine; Microengineering; Nanochemistry; Nanocomposites; Nanorods; Nanotechnology; Original Paper; Oxidation; Palladium; Silver chloride; Sol-gel processes; Synergistic effect; Nanointerfaces; Electrocatalyst; Carbon aerogels; Mesalazine; Conducting network
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-021-04789-y

We prepared, for the first time, carbon aerogels support on Pd–WO
3
nanorods (CAs/Pd–WO
3
) hybrid nanocomposite via sol-gel and microwave-assisted methods. The as-prepared CAs/Pd–WO
3
-modified electrode was used as effective electrocatalyst for nanomolar level detection of mesalazine (MSA). The typical porous nature of carbon aerogels effectively prevented the aggregation of Pd-doped WO
3
nanorods and increased the electrochemically active surface area. In addition, the Pd–WO
3
nanointerface provides intrinsic improvement of the electrocatalytic activity and stability for the electrochemical oxidation process, and the interconnected conducting network of the porous surfaces of CAs accelerated rapid electron transport at the working electrode. The synergistic effect of the CAs/Pd–WO
3
architecture has excellent electrocatalytic activity for the detection of MSA with high sensitivity of 2.403 ± 0.004 μA μM
−1
 cm
−2
, low detection limit of 0.8 ± 0.3 nM and wide linear response from 0.003–350 μM at a low applied potential of 0.30 V vs. Ag|AgCl. Satisfactory results were observed for its analytical performance in detecting MSA in human blood serum and urine samples, and recoveries ranged from 98.8 to 100.4%. We believe that the architecture of the modified CAs/Pd–WO
3
electrocatalysts can be effectively used in clinical applications for the detection of MSA.
Graphical abstract