Sleep-disordered breathing, glucose intolerance, and insulin resistance: The Sleep Heart Health Study

• Published in: American journal of epidemiology Vol. 160; no. 6; pp. 521 - 530
• Main Authors: PUNJABI, Naresh M, SHAHAR, Eyal, REDLLNE, Susan, GONLLEB, Daniel J, GLVELBE, Rachel, RESNICK, Helalne E
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 15-09-2004; Oxford Publishing Limited (England)
• Subjects: Aged; Analysis. Health state; Biological and medical sciences; Blood Gas Analysis; Body Constitution; Body Mass Index; Cohort Studies; Confounding Factors (Epidemiology); Cross-Sectional Studies; Diabetes Mellitus, Type 2 - etiology; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Epidemiology; Fasting; Female; General aspects; Glucose; Glucose Intolerance - diagnosis; Glucose Intolerance - etiology; Glucose Intolerance - metabolism; Glucose Tolerance Test; Humans; Insulin; Insulin resistance; Insulin Resistance - physiology; Linear Models; Male; Medical sciences; Middle Aged; Multivariate Analysis; Nervous system (semeiology, syndromes); Neurology; Oxyhemoglobins - metabolism; Pneumology; Polysomnography; Public health. Hygiene; Public health. Hygiene-occupational medicine; Research Design - standards; Respiratory system; Respiratory system : syndromes and miscellaneous diseases; Risk Factors; Severity of Illness Index; Sleep Apnea Syndromes - complications; Sleep Apnea Syndromes - diagnosis; Sleep disorders; Endocrinopathy; Heart; Human; Pancreatic hormone; Nervous system diseases; Sleep apnea syndrome; type II; glucose intolerance; insulin resistance; respiration; sleep; sleep apnea syndromes; Respiratory disease; Diabetes mellitus; Sleep disorder; Glucose; Insulin; Target tissue resistance; Sleep; Circulatory system; Sleep wake cycle; Neurological disorder; Respiration; Impaired glucose tolerance; Public health
• ISSN: 0002-9262; 1476-6256; 0002-9262
• DOI: 10.1093/aje/kwh261

Clinic-based studies suggest that sleep-disordered breathing (SDB) is associated with glucose intolerance and insulin resistance. However, in the available studies, researchers have not rigorously controlled for confounding variables to assess the independent relation between SDB and impaired glucose metabolism. The objective of this study was to determine whether SDB was associated with glucose intolerance and insulin resistance among community-dwelling subjects (n=2,656) participating in the Sleep Heart Health Study (1994-1999). SDB was characterized with the respiratory disturbance index and measurements of oxygen saturation during sleep. Fasting and 2-hour glucose levels measured during an oral glucose tolerance test were used to assess glycemic status. Relative to subjects with a respiratory disturbance index of less than 5.0 events/hour (the reference category), subjects with mild SDB (5.0-14.9 events/hour) and moderate to severe SDB (> or =15 events/hour) had adjusted odds ratios of 1.27 (95% confidence interval: 0.98, 1.64) and 1.46 (95% confidence interval: 1.09, 1.97), respectively, for fasting glucose intolerance (p for trend < 0.01). Sleep-related hypoxemia was also associated with glucose intolerance independently of age, gender, body mass index, and waist circumference. The results of this study suggest that SDB is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus.