Remarkable catalytic activity of [PdCl2(CH3CN)2] in Suzuki–Miyaura cross-coupling reaction in aqueous media under mild conditions

• Published in: Journal of molecular catalysis. A, Chemical Vol. 371; pp. 118 - 124
• Main Authors: Ganesamoorthy, S., Shanmugasundaram, K., Karvembu, R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-05-2013; Elsevier
• Subjects: Aryl halide; Boronic acid; Catalysis; Chemistry; Exact sciences and technology; General and physical chemistry; Palladium(II); Suzuki–Miyaura coupling; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry; Water solvent; Suzuki–Miyaura coupling; Boronic acid; Palladium(II); Water solvent; Aryl halide; Water; Catalytic reaction; Acids; Palladium II; Haloarene; Suzuki Miyaura cross coupling; Palladium complex; Suzuki-Miyaura coupling
• ISSN: 1381-1169; 1873-314X
• DOI: 10.1016/j.molcata.2013.01.029

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► [PdCl2(CH3CN)2] was found to catalyze the Suzuki–Miyaura cross coupling reaction. ► The method is general, green and applied to various aryl halides and boronic acids. ► Chemoselectivity of [PdCl2(CH3CN)2]/H2O catalytic system was studied.
[PdCl2(CH3CN)2] (2mol%) was found to be an efficient catalyst for the Suzuki–Miyaura cross coupling reaction between aryl bromide and aryl boronic acid in water solvent at 45°C. The scope of the protocol was extended to various aryl bromides and aryl boronic acids. In general, an effective method has been developed for the Suzuki–Miyaura cross coupling reaction by using a phosphine-free Pd catalyst.