Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis

• Published in: Bioorganic & medicinal chemistry letters Vol. 22; no. 8; pp. 2902 - 2905
• Main Authors: Sureram, Sanya, Senadeera, Sarath P.D., Hongmanee, Poonpilas, Mahidol, Chulabhorn, Ruchirawat, Somsak, Kittakoop, Prasat
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 15-04-2012; Elsevier
• Subjects: Alkaloids; Alkaloids - chemistry; Alkaloids - pharmacology; Antibacterial agents; antibacterial properties; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimycobacterial activity; Antitubercular Agents - chemistry; Antitubercular Agents - pharmacology; Benzylisoquinolines - chemistry; Benzylisoquinolines - pharmacology; Biological and medical sciences; Bisbenzylisoquinoline; Clinical isolates; Drug resistance; Drug Resistance, Multiple, Bacterial - drug effects; Humans; Magnetic Resonance Spectroscopy; Medical sciences; Menispermaceae - chemistry; Microbial Sensitivity Tests; Minimum inhibitory concentration; Molecular Structure; Multidrug-resistant tuberculosis; multiple drug resistance; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Pharmacology. Drug treatments; Plant Extracts - pharmacology; Plant Roots - chemistry; scaffolds; Tiliacora; Tiliacora triandra; Tuberculosis, Multidrug-Resistant - drug therapy; Alkaloids; Multidrug-resistant tuberculosis; Mycobacterium tuberculosis; Tiliacora triandra; Antimycobacterial activity; Root; Pharmacognosy; Mycobacterial infection; Biological activity; Medicinal plant; Infection; Alkaloid; Tuberculosis; Mycobacteriales; Multiple resistance; Bacteriosis; Mycobacteriaceae; Bacteria; Actinomycetes; Antituberculous agent; Antibacterial agent
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2012.02.053

Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2′-nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13′-bromo-tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1–4 showed MIC values ranging from 0.7 to 6.2μg/ml, but they exhibited the MIC value at 3.1μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity.