Approaches for in vitro propagation and production of plumbagin in Plumbago spp

• Published in: Applied microbiology and biotechnology Vol. 107; no. 13; pp. 4119 - 4132
• Main Authors: Pandey, Devendra Kumar, Katoch, Kajal, Das, Tuyelee, Majumder, Madhumita, Dhama, Kuldeep, Mane, Abhijit Bhagwan, Gopalakrishnan, Abilash Valsala, Dey, Abhijit
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-07-2023; Springer; Springer Nature B.V
• Subjects: Analysis; Biomedical and Life Sciences; Biosynthesis; Biotechnology; Carcinogens; Diabetes mellitus; Fertility; Fungicides; Identification and classification; Inflammation; Inoculation; Life Sciences; Mass production; Metabolites; Methods; Microbial Genetics and Genomics; Microbiology; Microorganisms; Mini-Review; Naphthoquinones - chemistry; Pharmaceutical industry; Pharmaceutical Preparations; Pharmaceuticals; Plant propagation; Plant species; Plantlets; Plumbagin; Plumbaginaceae; Plumbaginaceae - chemistry; Plumbaginaceae - metabolism; Plumbago auriculata; Propagation; Quinone; Shrubs; Sustainable production; India; Micropropagation; Elicitation; In vitro propagation; Plumbagin; Plumbago
• ISSN: 0175-7598; 1432-0614
• DOI: 10.1007/s00253-023-12511-6

The genus
Plumbago
(family
Plumbaginaceae
), commonly known as leadwort, is a sub-tropical shrub that produces secondary metabolite plumbagin, which is employed by pharmaceutical companies and in clinical research. Plumbagin is a potent pharmaceutical because of its anti-microbial, anti-malarial, antifungal, anti-inflammatory, anti-carcinogenic, anti-fertility, anti-plasmodium, antioxidant, anti-diabetic, and other effects. This review documents the biotechnological innovations used to produce plumbagin. The use of modern biotechnological techniques can lead to a variety of benefits, including better yield, increased extraction efficiency, mass production of plantlets, genetic stability, increased biomass, and more. Large-scale in vitro propagation is necessary to minimize over-exploitation of the natural population and allow the use of various biotechnological techniques to improve the plant species and secondary metabolite production. During in vitro culture, optimum conditions are requisites for explant inoculation and plant regeneration. In this review, we provide information on various aspects of plumbagin, depicting its structure, biosynthesis, and biotechnological aspects (both conventional and advanced) along with the future prospects.
Key Points
• Critical assessment on in vitro biotechnology in Plumbago species
• In vitro propagation of Plumbago and elicitation of plumbagin
• Biosynthesis and sustainable production of plumbagin