Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis
Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of p...
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| Published in: | Frontiers in pharmacology Vol. 11; p. 583354 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Frontiers Media S.A
02-10-2020
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. In this narrative review, we provided a comprehensive overview of the therapeutic management of autoimmune bullous diseases in pregnant and breastfeeding women, focusing on pemphigus and pemphigoid gestationis. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Aurora Parodi, University of Genoa, Italy; Gabriele Simonini, University of Florence, Italy This article was submitted to Obstetric and Pediatric Pharmacology, a section of the journal Frontiers in Pharmacology Edited by: Cecilia Beatrice Chighizola, Istituto Auxologico Italiano (IRCCS), Italy |
| ISSN: | 1663-9812 1663-9812 |
| DOI: | 10.3389/fphar.2020.583354 |