Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis

Identification of Key Biomarkers in Systemic Lupus Erythematosus by a Multi-Cohort Analysis

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple body systems with heterogeneous clinical manifestations. Since gene expression analyses have been accomplished on diverse types of samples to specify SLE-related genes, single-cohort transcriptomics have not produced r...

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Bibliographic Details
Published in:Frontiers in immunology Vol. 13; p. 928623
Main Authors: Wei, Meilin, Dong, Qiguan, Chen, Shaoqiu, Wang, Junlong, Yang, Hua, Xiong, Qin
Format: Journal Article
Language:English
Published: Frontiers Media S.A 04-07-2022
Subjects:
diagnosis
immune cells
Immunology
multi-cohort
SLE
transcriptome
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Summary:Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple body systems with heterogeneous clinical manifestations. Since gene expression analyses have been accomplished on diverse types of samples to specify SLE-related genes, single-cohort transcriptomics have not produced reliable results. Using an integrated multi-cohort analysis framework, we analyzed whole blood cells from SLE patients from three transcriptomics cohorts (n=1222) and identified a five-gene signature that distinguished SLE patients from controls. We validated the diagnostic performance of this five-gene signature in six independent validation cohorts (n= 469), with an area under the receiver operating characteristic curve of 0.88 [95% CI 0.7 − 0.96]. This five-gene signature may be associated with the proportion of SLE immune cells, and generalizable across ages and sample types with real diagnostic value for clinical application.
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Edited by: Xiaoyan Wang, Shanghai Jiao Tong University, China
Reviewed by: Jian Yin Zou, Shanghai Jiao Tong University, China; Kaifeng Guo, Fudan University, China
These authors have contributed equally to this work
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.928623