Total Colectomy as a Part of Ultra-Radical Surgery for Ovarian Cancer—Short- and Long-Term Outcomes

• Published in: Current oncology (Toronto) Vol. 28; no. 5; pp. 4223 - 4233
• Main Authors: Szubert, Sebastian, Skowyra, Artur, Wójtowicz, Andrzej, Pawlowicz, Pawel, Szczepkowski, Marek, Nowakowski, Blazej, Wicherek, Lukasz
• Format: Journal Article
• Language: English
• Published: MDPI 18-10-2021; MDPI AG
• Subjects: cytoreductive surgery; debulking surgery; ovarian cancer surgery; total colectomy
• ISSN: 1718-7729; 1198-0052; 1718-7729
• DOI: 10.3390/curroncol28050358

(1) Background: The aim of this study was to assess the outcomes for patients who underwent total colectomy (TC) as a part of surgery for ovarian cancer (OC). (2) Methods: We performed a retrospective analysis of 1636 OC patients. Residual disease (RD) was reported using Sugarbaker’s completeness of cytoreduction score. (3) Results: Forty-two patients underwent TC during primary debulking surgery (PDS), and four and ten patients underwent TC during the interval debulking surgery (IDS) and secondary cytoreduction, respectively. The median overall survival (mOS) in OC patients following the PDS was 45.1 months in those with CC-0 (21%) resection, 11.1 months in those with CC-1 (45%) resection and 20.0 months in those with CC-2 (33%) resection (p = 0.28). Severe adverse events were reported in 18 patients (43%). In the IDS group, two patients survived more than 2 years after IDS and one patient died after 28.6 months. In the recurrent OC group, the mOS was 6.9 months. Patient age above 65 years was associated with a shortened overall survival (OS) and the presence of adverse events. (4) Conclusions: TC as a part of ultra-radical surgery for advanced OC results in high rates of optimal debulking. However, survival benefits were observed only in patients with no macroscopic disease.