Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis

• Published in: European archives of psychiatry and clinical neuroscience Vol. 273; no. 1; pp. 5 - 14
• Main Authors: Hernández-Díaz, Yazmin, Tovilla-Zárate, Carlos Alfonso, Castillo-Avila, Rosa Giannina, Juárez-Rojop, Isela Esther, Genis-Mendoza, Alma Delia, López-Narváez, María Lilia, Villar-Juárez, Guillermo Efrén, González-Castro, Thelma Beatriz
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2023; Springer; Springer Nature B.V
• Subjects: Analysis; Behavior; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Literature reviews; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Meta-analysis; Neurosciences; Original Paper; Polymorphism; Psychiatry; Sensitivity analysis; Statistical analysis; Suicidal behavior; Suicides & suicide attempts; HTR1A; Suicidal behavior; rs6295; Polymorphism; Meta-analysis
• ISSN: 0940-1334; 1433-8491
• DOI: 10.1007/s00406-022-01500-x

Several association studies have indicated that the
HTR1A
gene is associated with suicidal behavior (SB). Thus, a systematic assessment of the association of
HTR1A
was performed based on a literature review and pooled analysis. Four electronic databases were comprehensively searched to find and pinpoint all case–control articles related to this study. When analyzing the genetic association with SB, data were divided into: (A) SB cases vs. healthy controls and (B) SB cases vs. psychiatric controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were assessed as measures of association. Heterogeneity among included studies was analyzed using sensitivity test and Q statistics. Publication bias was also explored by Egger and rank correlation test. Thirteen case–control studies were selected in this meta-analysis, involving 2817 SB patients, 2563 healthy controls and 545 psychiatric controls. In the overall comparison between SB cases and healthy controls, result showed that the rs6295 polymorphisms of
HTR1A
gene was associated with SB, but only when using the recessive model (OR = 2.21, 95% CI = 1.80–2.71,
P
 < 0.001). In the smaller sample size comparison between SB and psychiatric controls, no significant association was detected with rs6295 in any of the five genetics models tested. The present meta-analysis suggests that rs6295 polymorphism of
HTR1A
gene could increase the risk for SB. Well-designed studies with more patients will be required to validate these results.