Heart Rhythm Disturbances Caused by Injection of Cholinesterase Inhibitor Physostigmine to Rats during the Early Ontogeny

Heart Rhythm Disturbances Caused by Injection of Cholinesterase Inhibitor Physostigmine to Rats during the Early Ontogeny

Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly dif...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 165; no. 1; pp. 44 - 47
Main Authors: Sizonov, V. А., Dmitrieva, L. E.
Format: Journal Article
Language:English
Published: New York Springer US 01-05-2018
Springer
Subjects:
Animals
Animals, Newborn
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cholinesterase Inhibitors - pharmacology
Electrocardiography
Heart rate
Heart Rate - drug effects
Internal Medicine
Laboratory Medicine
Laws, regulations and rules
Pathology
Physostigmine
Physostigmine - pharmacology
Rats
Rats, Wistar
early ontogeny
heart rhythm
physostigmine
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Summary:Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly differed by the magnitude, which suggests that that maturation of cholinergic structures involved in the regulation of cardiac activity is completed during the early postnatal ontogeny.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4095-9